Anti-virus protection by p53 inducible factor

p53诱导因子的抗病毒保护

• 批准号: 22790387
• 负责人: SHIN-YA Masaharu
• 金额: $ 2.5万
• 依托单位: Kyoto Prefectural University of Medicine
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22790387/
• 关键词: P53; p53; ウイルス感染

p53 is a important for tumor suppressor gene, while it's contribution of anti-virus protection remains unclear. We found that p53 induced Fbw7βworked to anti-virus protection. Although three isoforms existed in Fbw7, it was shown that Fbw7βstrongly acts on anti-virus protection. These present results may lead to development of a novel antiviral drug.

p53是一个重要的抑癌基因，但其抗病毒保护的贡献尚不清楚。我们发现p53诱导的Fbw7β具有抗病毒保护作用。尽管Fbw7存在三种异构体，但研究表明Fbw7β具有很强的抗病毒保护作用。目前的这些结果可能会导致新型抗病毒药物的开发。

项目成果

Gain-of-function and loss of function analyses in vivo of transcriptional factor and cytokine genes using Epstein唯err virus傭ased episomal vectors, and their implication to novel strategies of gene therapy and regenerative medicine

使用爱泼斯坦病毒附加型载体对转录因子和细胞因子基因进行体内功能获得和功能丧失分析，及其对基因治疗和再生医学新策略的意义

• 发表时间: 2010
• 作者: Kishida T;Nakai N;Matsui M;Yoshimoto K;Nakano H;Shin-Ya M;Shimada T;Nakai S;Hisa Y;Katoh N;Mazda O.
• 通讯作者: Mazda O.

MDR1a/lb gene silencing enhances drug sensitivity in rat fibroblast-like synoviocytes

MDR1a/lb基因沉默增强大鼠成纤维细胞样滑膜细胞的药物敏感性

• 发表时间: 2010
• 期刊: J Gene Med
• 影响因子: 3.5
• 作者: Honjo K;KA. Takahashi;0.Mazda;T. Kishida;M. Shinya;D. Tokunaga;Y. Arai;A. Inoue;N. Hiraoka;J. Imanishi & T. Kubo
• 通讯作者: J. Imanishi & T. Kubo

Interleukin-28B(IL-28B) acts synergistically with cisplatin to suppress the growth of head and neck squamous cell carcinoma

白介素28B（IL-28B）与顺铂协同抑制头颈鳞状细胞癌的生长

• 发表时间: 2011
• 期刊: J Immunother
• 影响因子: 3.9
• 作者: Yoshimoto K;T. Kishida;H. Nakano;M. Matsui;M. Shin-Ya;T. Shimada;S. Nakai;J. Imanishi;M. Takeuchi;Y. Hisa & O. Mazda
• 通讯作者: Y. Hisa & O. Mazda

Interleukin-28B Acts Synergistically With Cisplatin to Suppress the Growth of Head and Neck Squamous Cell Carcinoma

• DOI: 10.1097/cji.0b013e318204ed70
• 发表时间: 2011-03
• 期刊: Journal of Immunotherapy
• 影响因子: 3.9
• 作者: Koichiro Yoshimoto;T. Kishida;H. Nakano;M. Matsui;M. Shin-Ya;Taketoshi Shimada;S. Nakai;J. Imanishi;M. Takeuchi;Y. Hisa;O. Mazda

Early-stage blocking of Notch signaling inhibits the depletion of goblet cells in dextran sodium sulfate-induced colitis in mice

• DOI: 10.1007/s00535-010-0210-z
• 发表时间: 2010-06-01
• 期刊: JOURNAL OF GASTROENTEROLOGY
• 影响因子: 6.3
• 作者: Shinoda, Misumi;Shin-Ya, Masaharu;Yoshikawa, Toshikazu
• 通讯作者: Yoshikawa, Toshikazu