Regulatory gene expression by cohesin in malaria parasite

新的证据表明，在酵母和哺乳动物中，黏结蛋白复合物参与了基因表达的调节。然而，在疟原虫中，内聚复合体在基因表达调控中的精确作用仍然完全未被探索。因此，我们从疟原虫中克隆黏结蛋白并构建黏结蛋白标记的转基因疟原虫，以评估黏结蛋白在疟原虫基因组中的分布。内聚蛋白定位将揭示哺乳动物宿主与疟原虫不同发育阶段的基因表达机制。

The new evidence is emerging suggesting that the cohesin complex is involved in the regulation of gene expression in yeast and mammals. However, a precise role for the cohesion complex in the regulation of gene expression remains completely unexplored in malaria parasite. Thus we cloned cohesin from malaria parasite and generated the cohesin-tagged transgenic parasite to assess the cohesin distribution in the genome. Cohesin mapping would reveal the gene expression mechanism of different developmental stages between mammalian host and mosquito of malaria parasite.