Construction of T/B-Cell zone in neonatal Peyer's Patches

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Peripheral lymphoid tissues such as lymph nodes and Peyer's patches are the organs where all cellular components required for immune response are assembled around the antigen processing cells. In order to mount efficient immune reactions against a small dose of antigen, a highly organized tissue architecture with distinct zones for T and B cells have to be developed. In this study, we present the evidence that lymphoid tissue inducer cells that initially play the pivotal role in the formation of PP anlagen are involved in the formation of B and T cell zones in neonatal mice. In order to migrate over different zones, PPi undergoes chemokine receptor switches.