Construction of T/B-Cell zone in neonatal Peyer's Patches

新生儿派尔氏淋巴结 T/B 细胞区的构建

• 批准号: 22790483
• 负责人: NAKAGAWA Reiko
• 金额: $ 2.33万
• 依托单位: The Institute of Physical and Chemical Research
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22790483/
• 关键词: パイエル板; CXCR4; リンホトキシン; Lymphoid tissue inducer(LTi); Lymphoid tissue inducer cell; Peyer's Patch

Peripheral lymphoid tissues such as lymph nodes and Peyer's patches are the organs where all cellular components required for immune response are assembled around the antigen processing cells. In order to mount efficient immune reactions against a small dose of antigen, a highly organized tissue architecture with distinct zones for T and B cells have to be developed. In this study, we present the evidence that lymphoid tissue inducer cells that initially play the pivotal role in the formation of PP anlagen are involved in the formation of B and T cell zones in neonatal mice. In order to migrate over different zones, PPi undergoes chemokine receptor switches.

外周淋巴组织如淋巴结和派尔集合淋巴结是免疫应答所需的所有细胞组分围绕抗原加工细胞组装的器官。为了对小剂量抗原产生有效的免疫反应，必须开发具有T和B细胞的不同区域的高度组织化的组织结构。在这项研究中，我们提出的证据表明，淋巴组织诱导细胞，最初发挥关键作用的PP原基的形成参与新生小鼠的B和T细胞区的形成。为了在不同区域上迁移，PPi经历趋化因子受体开关。

项目成果

LT-dependent switch from CXCR5 to CXCR4 is required for relocation of lymphoid tissue inducer cells from B- to T-cell zone of Peyer's patch

淋巴组织诱导细胞从派尔氏集结的 B 细胞区重新定位到 T 细胞区需要 LT 依赖性从 CXCR5 到 CXCR4 的转换

• 发表时间: 2010
• 作者: 齋藤夕子、清野薫子;他;作間未織;中川れい子
• 通讯作者: 中川れい子