Establishment of the Enhancement Effect of 2-Arachidonylglycerol on Antimicrobial Peptide Induction

抗菌肽（Antimicrobial peptides，AMPs）是肠道上皮细胞分泌的一种抗菌肽，是肠道感染的起点，参与肠道的先天性免疫。我们研究了2-花生四烯酸甘油（2-AG）分泌AMP和注射2-AG抑制病原微生物的感染。本研究表明，2-AG从Caco-2细胞分泌AMP。此外，2-AG抑制E.大肠杆菌标记物。综上所述，我们发现2-AG可能通过肠上皮细胞分泌AMP来抑制病原微生物的感染。

Antimicrobial peptides(AMPs) are secreted from intestinal epithelium cell as the starting point for infection, contribute to innate immunity in the intestinal tract. We investigated that the 2-arachidonylglycerol(2-AG) secretes AMPs and that injection of 2-AG suppresses infection of pathogenic microorganism. The present study showed that 2-AG secreted the AMPs from Caco-2 cells. Furthermore, 2-AG suppressed the total number of E. coli marker during 6-hour period. Taken together, we found that 2-AG might suppress against pathogenic microorganism infection by secreting AMPs from intestinal epithelium cells.