Diagnostic value of immunohistochemical expression of IMP3 in transpapillary biliary forceps biopsy samples of extrahepatic bile duct carcinoma

本研究的目的是阐明S100P和dimp3免疫组化表达在经乳头胆道钳活检（TBFB）标本中的诊断和预后价值。回顾性收集80例患者的TBFB样本（肝外胆管癌68例，良性12例）。当使用imp3阳性染色和/或阳性组织学作为恶性肿瘤的判定标准时，其敏感性、特异性和准确性分别达到89.7%、91.7%和90.0%。单因素分析（P= 0.033）和多因素分析（P= 0.039）显示s100p阳性的肝外胆管癌患者生存期明显缩短。

The objective of this study is to clarify the diagnostic and prognostic value of immunohistochemical expression of S100P andIMP3 in transpapillary biliary forceps biopsy (TBFB) samples. The TBFB samples were collected from 80 patients (extrahepatic bile duct carcinoma, 68 patients; benign, 12 patients), retrospectively. The sensitivity, specificity and accuracy achieved 89.7 %, 91.7 % and 90.0 %, respectively, when using positive staining for IMP3and/or positive histology as a maker of malignancy. While univariate (P= 0.033) and multivariate (P= 0.039) analysis revealed that S100P-positive extrahepatic bile duct carcinoma patients showed significantly shorter survival.