Study on epigenetic changes in fetal life evoked by gestational infection or malnutrition

本研究的目的是探讨某些胚胎环境或出生后的儿童保育对后代生长和迟发性基因表达过程中存活率的任何改变或有害影响。 以社区为基础的人类研究和动物实验同时进行。 在印度尼西亚松巴进行的一项队列研究表明，近亲结婚可能会降低5岁以上后代的存活率，但会导致高生育率。 孟加拉国母婴对接触无机砷（iAs）进行了调查，以检查iAs的敏感性，然后进行iAs暴露于小鼠的实验。

The aim of this study was to explore any alterations or deleterious effects on survival rate during growth and late-onset gene expressions in future generations by certain embryonal environments or child-care after birth. Both community-based human study and animal experiments were conducted in parallel. A cohort study in Sumba, Indonesia, revealed that consanguineous marriages might decrease the survival rate of the offspring who lived over 5 years old, but lead to high fertility. Bangladeshi mother-infant pairs exposed to inorganic arsenic (iAs) were investigated to examine susceptibility to iAs, followed by experiments for iAs exposure to mice.