Roles of HIF-1α on wound healing of airway epithelial cells

当划痕刺激呼吸道上皮细胞时，缺氧诱导因子-1α积聚到位于创缘的细胞的胞核中。缺氧诱导因子-1α缺失可促进呼吸道上皮细胞损伤愈合。相反，HIF-1α诱导剂可抑制细胞的创伤愈合，这种作用可被HIF-1α剥夺所减弱。这些结果表明，划痕伤诱导的缺氧诱导因子-1α是呼吸道上皮细胞创伤修复的负性调节因子。

When airway epithelial cells were stimulated by scratch wound, hypoxia-inducible factor(HIF)-1α is accumulated into the nucleus of the cells located at the wound margin. HIF-1α deprivation promoted wound healing of airway epithelial cells. By contrast, HIF-1α inducer suppressed wound healing of the cells, and this effect was attenuated by HIF-1α deprivation. These results suggest that scratch wound-induced HIF-1α is a negative regulator for wound healing of airway epithelial cells.