Roles of HIF-1α on wound healing of airway epithelial cells

当气道上皮细胞受到抓伤刺激时，缺氧诱导因子(HIF)-1α在创面边缘的细胞核内积累。HIF-1α缺失促进气道上皮细胞创面愈合。相反，HIF-1α诱导剂抑制了细胞的创面愈合，这种作用被HIF-1α剥夺后减弱。这些结果表明，划伤诱导的HIF-1α是气道上皮细胞创面愈合的负调控因子。

When airway epithelial cells were stimulated by scratch wound, hypoxia-inducible factor(HIF)-1α is accumulated into the nucleus of the cells located at the wound margin. HIF-1α deprivation promoted wound healing of airway epithelial cells. By contrast, HIF-1α inducer suppressed wound healing of the cells, and this effect was attenuated by HIF-1α deprivation. These results suggest that scratch wound-induced HIF-1α is a negative regulator for wound healing of airway epithelial cells.