Innovation of anti-cachectic therapy with anti-tumor effect for pancreatic cancer

癌症恶病质是晚期胰腺癌患者死亡的主要原因。抗病毒性药物与抗肿瘤药物合用是治疗胰腺癌的有效方法。本研究旨在揭示胰腺癌恶病质小鼠模型中抑制恶病质和肿瘤进展的靶分子。本研究明确白细胞介素-6是有希望的靶点，人胰腺癌细胞神经侵袭小鼠模型适合用于癌症恶病质模型。IL-6通路的抑制抑制了神经侵袭，但在我们高贵的癌症恶病质模型中，很难证实癌症恶病质的改善。

Cancer cachexia is a major cause of death in advanced pancreatic cancer. Anti-cachectic drug concominant with anti-tumor effect is useful in treatment for patients with pancreatic cancer. This study aimed to reveal the target molecule whose inhibition suppresses cachexia and tumor progression in a noble murine model for cachexia of pancreatic cancer. This study clearly showed interleukin-6 is promising target, and murine model of neural invasion using human pancreatic cancer cell is appropriated for the model of cancer cachexia. The inhibition of IL-6 pathways suppressed neural invasion, but it was difficult to confirm the improvement of cancer cachexia in our noble model of cancer cachexia.