Molecular mechanism of astrocyte-related cachexia and pain due to neural invasion of pancreatic cancer

星形胶质细胞相关胰腺癌神经侵袭性恶病质和疼痛的分子机制

• 批准号: 24790669
• 负责人: MITSUNAGA Shuichi
• 金额: $ 2.66万
• 依托单位: National Center of Neurology and Psychiatry
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24790669/
• 关键词: 緩和医療; 膵がん; 悪液質; 神経浸潤; RAGE; S100A4; CCL7; マウスモデル; アストロサイト; S100P; S100A9

The reaction of the nervous system to neural invasion (N-inv) may lead to cachexia and pain in pancreatic cancer (PCa). The N-inv model was created by injecting Capan-1 cells into the left sciatic nerve of severe combined immunodeficiency mice. The N-inv model was compared to a sham operation group. Propentofylline (PPF), an inhibitor of astrocytic activation, was administered daily into the abdominal cavity. Pain and body weight (BW) were measured weekly. Mice were euthanized 6 weeks after surgery.Pain and astrocytic activation were observed 2 weeks after the start of N-inv and maintained throughout the experiment. Loss of BW began at 4 weeks and was worse at 6 weeks. PPF treatment inhibited pain, astrocytic activation, and BW loss in the N-inv model. The reaction of the nervous system to N-inv leads to cachexia in PCa. The reaction of the nervous system to N-inv leads to cachexia in PCa.

神经系统对神经侵袭（N-inv）的反应可能导致胰腺癌（PCa）出现恶病质和疼痛。 N-inv模型是通过将Capan-1细胞注射到严重联合免疫缺陷小鼠的左侧坐骨神经中而创建的。将 N-inv 模型与假手术组进行比较。丙茶碱（PPF）是一种星形细胞活化抑制剂，每天注入腹腔。每周测量疼痛和体重（BW）。手术后6周对小鼠实施安乐死。N-inv开始后2周观察疼痛和星形胶质细胞活化，并在整个实验过程中维持。体重损失从第 4 周开始，到第 6 周更严重。 PPF 治疗抑制了 N-inv 模型中的疼痛、星形胶质细胞活化和体重损失。神经系统对 N-inv 的反应导致 PCa 恶病质。神经系统对 N-inv 的反应导致 PCa 恶病质。

项目成果

血小板低値の肝細胞癌患者に対するSorafenib

索拉非尼治疗血小板水平低的肝细胞癌患者

• 发表时间: 2013
• 作者: 清水怜;桑原明子;奥山浩之;高橋秀明;大野泉;光永修一;篠原旭;小林美沙樹;船崎秀樹;近藤俊輔;森実千種;上野秀樹;奥坂拓志;池田公史
• 通讯作者: 池田公史

80歳以上の高齢者の切除不能膵癌症例に対するゲムシタビン療法の有効性と忍容性

吉西他滨治疗 80 岁及以上不可切除胰腺癌患者的疗效和耐受性

• 发表时间: 2012
• 作者: 小林美沙樹;奥山浩之;船崎秀樹;桑原明子;高橋秀明;大野泉;清水怜;光永修一;池田公史;市田泰彦;和泉啓司郎
• 通讯作者: 和泉啓司郎

肝転移を有する膵腺房細胞癌に対しゲムシタビン塩酸塩とS-1併用療法を行った2例.

盐酸吉西他滨联合S-1治疗胰腺腺泡细胞癌肝转移2例

• 发表时间: 2012
• 作者: 桑原明子;光永修一;清水怜;大野泉;高橋秀明;奥山浩之;池田公史.
• 通讯作者: 池田公史.

Treatment outcome for systemic chemotherapy for recurrent pancreatic cancer after postoperative adjuvant chemotherapy.

术后辅助化疗后复发性胰腺癌全身化疗的治疗结果。

• DOI: 10.1016/j.pan.2012.07.016
• 发表时间: 2012
• 期刊: Pancreatology
• 影响因子: 3.6
• 作者: Taniyama TK;Morizane C;Nakachi K;Nara S;Ueno H;Kondo S;Kosuge T;Shimada K;Esaki M;Ikeda M;Mitsunaga S;Kinoshita T;Konishi M;Takahashi S;Okusaka T.
• 通讯作者: Okusaka T.

Characterization of patient with high serum level of IL-6 in advanced panceratic cancer

晚期胰腺癌高血清 IL-6 水平患者的特征

• 发表时间: 2013
• 作者: 三浦智史;光永修一;清水怜;大野泉;高橋秀明;奥山浩之;桑原明子;池田公史
• 通讯作者: 池田公史