Development of the novel liver repair therapy with interaction between bone marrow stem cells and macrophages

肝硬化小鼠骨髓干细胞移植后浸润到肝脏的巨噬细胞主要来源于受体，基质衍生因子1/ CXCR4信号通路与巨噬细胞从骨髓向肝脏迁移密切相关。此外，巨噬细胞表达的基质金属蛋白酶9可以减少肝脏中的胶原纤维。我们将通过骨髓干细胞和巨噬细胞的相互作用，开发新的肝修复疗法来改善肝纤维化。

Macrophages which are infiltrated into the liver after bone marrow stem cell transplantation to cirrhotic mice are mainly originated from recipients and stromal derived factor 1/ CXCR4 signaling is closely related to the migration of macrophages from bone marrow to the liver. And also, matrix metalloproteinase 9 expressed by macrophages can reduce collagen fiber in the liver. We will develop the novel liver repair therapy to improve hepatic fibrosis with interaction between bone marrow stem cells and macrophages.