Development of a novel therapy for hepatic fibrosis using combination of partial splenic embolization and autologous bone marrow infusion

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A new mouse model of partial splenic artery ligation (PSL) was originally developed and the procedure induced 67% of splenic infarction. Splenectomy (SP) or PSL was performed for cirrhotic mice induced by continuous intraperitoneal injection of carbon tetrachloride. Platelet counts were significantly increased by SP as compared to by PSL, but there were no statistical differences in other results between two procedures. Partial splenic embolization for cirrhotic human patients dramatically increased various growth factors such hepatocyte growth factor and some collagenases including matrix metalloproteinase, and similar results were shown in cirrhotic mice that underwent PSL. Near the future, we will clarify the synergistic effects on an improvement in hepatic fibrosis by combination of PSL and bone marrow cell infusion.