A new molecular target therapy for gastric can cer targeting nuclear translocation of the CTF of EGFR ligands

EGFR配体CTF核易位的胃癌新分子靶向治疗

• 批准号: 22790665
• 负责人: SHIMURA Takaya
• 金额: $ 2.58万
• 依托单位: Nagoya City University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22790665/
• 关键词: 胃癌; 分子標的治療; HB-EGF; Amphiregulin; EGFR

HB-EGF-CTF nuclear translocation increased motility and invasion of gastric cancer cell. The nuclear immunoreactivity of HB-EGF-CTF was significantly increased in stage pT3/4 tumors compared with pT1/2 tumors in human gastric cancer. These results suggested that HB-EGF-CTF nuclear translocation induce gastric cancer invasion(Shimura T, et al. BMC Cancer 2012, in press).AR nuclear translocation significantly induced chemoresistance in vitro and in vivo, and AR-nuclear staining was extracted as a significant poor prognostic factor in human gastric cancer. As these results, AR nuclear translocation reduces chemosensitivity to anti-cancer drugs and would be associated with poor prognosis in human gastric cancer(Yoshida M, Shimura T, et al. Cancer Sci 2012).

HB-EGF-CTF核转位增加胃癌细胞的运动和侵袭能力。HB-EGF-CTF在pT 3/4期胃癌中的表达明显高于pT 1/2期胃癌。这些结果表明，HB-EGF-CTF核易位诱导胃癌侵袭（Shimura T，et al. BMC Cancer 2012，in press）AR核易位在体外和体内显著诱导化学抗性，并且AR-核染色被提取为人胃癌中显著的不良预后因子。由于这些结果，AR核易位降低了对抗癌药物的化学敏感性，并且将与人胃癌的不良预后相关（Yoshida M，Shimura T，et al. Cancer Sci 2012）。

项目成果

Amphiregulin nuclear translocation might reduce chemosensitivity in gastric cancer.

双调蛋白核易位可能会降低胃癌的化疗敏感性。

• 发表时间: 2010
• 作者: 藤田浩司;米田正人;志村貴也;吉田道弘
• 通讯作者: 吉田道弘

The impact of cross-resistance between paclitaxel and docetaxel for metastatic gastric cancer

紫杉醇与多西他赛交叉耐药对转移性胃癌的影响

• 发表时间: 2012
• 期刊: Onkologie
• 影响因子: 0.3
• 作者: Shimura T;Kitagawa M;Yamada T;Yoshida M;Ebi M;Hirata Y;Mizushima T;Mizoshita T;Tanida S;Kataoka H;Kamiya T;Joh T
• 通讯作者: Joh T

Amphiregulin nuclear translocation might reduce chemosensitivity in gastric cancer

双调蛋白核易位可能降低胃癌的化疗敏感性

• 发表时间: 2010
• 作者: Yoshida M;Shimura T;Higashiyama S;Kataoka H;Joh T;et al.(2番目)
• 通讯作者: et al.(2番目)

The relationship between antitumor effects and relative dose intensity of S-1 plus cisplatin treatment for metastatic gastric cancer.

S-1联合顺铂治疗转移性胃癌的抗肿瘤作用与相对剂量强度的关系。

• 发表时间: 2012
• 期刊: Anticancer Research
• 影响因子: 2
• 作者: M. Kitagawa;T. Shimura;Tomonori Yamada;M. Ebi;Yoshikazu Hirata;T. Mizoshita;S. Tanida;H. Kataoka;T. Kamiya;T. Joh
• 通讯作者: T. Joh

HB-EGF-CTF nuclear translocation induces gastric cancer invasion.

HB-EGF-CTF核易位诱导胃癌侵袭。

• 发表时间: 2010
• 作者: 藤田浩司;米田正人;志村貴也
• 通讯作者: 志村貴也