Elucidation of mechanism of cardioprotective effect by wnt11 and development of therapeutic application
Elucidation of mechanism of cardioprotective effect by wnt11 and development of therapeutic application
批准号:
22790698
负责人:
KOBAYASHI Koichi
金额:
$2.5万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2011
中文摘要
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英文摘要
Wnt11 therapy using adeno-associated virus improved survival of mice with myocarditis by about 30%. We tried to clarify the mechanism to improve survival. We found wnt11 significantly suppressed the production of inflammatory cytokines from activated Raw cells which are cell line of macrophage. We showed wnt11 has therapeutic effect on virus-induced myocarditis.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
AAV9-wnt11 Gene Therapy Improves Cardiac Recovery After Myocardial Infarction by Modulating the inflammatory Response
AAV9-wnt11 基因疗法通过调节炎症反应改善心肌梗死后的心脏恢复
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Matsuzawa Y, Sugiyama S, Sugamura K, Nozaki T, Ohba K, Konishi M, Matsubara J, Sumida H, Kaikita K, Kojima S, Nagayoshi Y, Yamamuro M, Izumiya Y, Iwashita S, Matsui K, Jinnouchi H, Kimura K, Umemura S, Ogawa H., Ling Zeng, Yasushi Matsuzawa, 泉家康宏, 六反田拓, Taku rokutanda, 泉家康宏, Yasuhiro Izumiya, 泉家康宏, Taku Rokutanda, 小林光一]
通讯作者:
小林光一
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