Disordered expression of the homing receptor glycans on helper memory T cells in patients with severe bronchial asthma

1.支气管哮喘和特应性皮炎患者辅助性T（Th）细胞上硫酸化归巢受体聚糖的表达水平高于正常对照组。这些水平与特应性皮炎加重的频率显著相关，而非磺化转运th聚糖的表达水平与采集血样时疾病的严重程度相关。统计分析表明，巯基归甲受体聚糖在鉴别高复发性特应性皮炎患者方面具有潜在的应用价值。我们已经报道了硫转移酶基因HEC-GlcNAc6ST的转录调控机制。我们还揭示了HEC-GlcNAc6ST参与辅助性T细胞中硫酸酸化细胞粘附聚糖的合成。

1.The expression levels of the sulfated homing-receptor glycan on helper T(Th) cells were higher in patients with bronchial asthma or atopic dermatitis than those in normal controls. These levels were significantly correlated with frequency of exacerbation of atopic dermatitis, while the expression levels of non-sulfated Th-trafficking glycan were correlated with the disease severity at the time when the blood sample was collected. Statistic analysis suggested potential utility of the sulfated homing-receptor glycan for discriminating patients with highly recurrent atopic dermatitis.2.We have reported the mechanism of the transcriptional regulation of a sulfotransferase gene HEC-GlcNAc6ST. We have also revealed the involvement of HEC-GlcNAc6ST in the synthesis of a sulfated cell-adhesion glycan in helper T cells.