Disordered expression of the homing receptor glycans on helper memory T cells in patients with severe bronchial asthma

严重支气管哮喘患者辅助记忆 T 细胞上归巢受体聚糖表达紊乱

• 批准号: 22790774
• 负责人: SAKUMA Keiichiro
• 金额: $ 2.16万
• 依托单位: Aichi Cancer Center Research Institute
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22790774/
• 关键词: 閉塞性肺疾患; 喘息; ホーミング; メモリーT細胞; 糖鎖; ヘルパーメモリーT細胞; 硫酸基転移酵素; 転写; アトピー性皮膚炎

1.The expression levels of the sulfated homing-receptor glycan on helper T(Th) cells were higher in patients with bronchial asthma or atopic dermatitis than those in normal controls. These levels were significantly correlated with frequency of exacerbation of atopic dermatitis, while the expression levels of non-sulfated Th-trafficking glycan were correlated with the disease severity at the time when the blood sample was collected. Statistic analysis suggested potential utility of the sulfated homing-receptor glycan for discriminating patients with highly recurrent atopic dermatitis.2.We have reported the mechanism of the transcriptional regulation of a sulfotransferase gene HEC-GlcNAc6ST. We have also revealed the involvement of HEC-GlcNAc6ST in the synthesis of a sulfated cell-adhesion glycan in helper T cells.

1.哮喘和特应性皮炎患者辅助性T(Th)细胞表面硫化归巢受体糖链的表达水平明显高于正常对照组。这些水平与特应性皮炎的加重频率显著相关，而非硫化Th-转运多糖的表达水平与采集血液样本时的疾病严重程度相关。统计分析表明，硫酸归巢受体葡聚糖有可能用于鉴别高度复发的特应性皮炎患者。2.我们已经报道了磺基转移酶基因HEC-GlcNAc6ST转录调控的机制。我们还揭示了HEC-GlcNAc6ST参与了辅助性T细胞中一种硫酸盐化细胞粘附性多糖的合成。

项目成果

Th2-specific homing ligands involved in recurrent atopic dermatitis exacerbations.

Th2 特异性归巢配体参与复发性特应性皮炎恶化。

• 发表时间: 2011
• 作者: 佐久間圭一朗;古橋卓也;近藤幸子;矢部宇一郎;大森勝之;森田明理;神奈木玲児
• 通讯作者: 神奈木玲児

Transcription factors c-Myc and CDX2 mediate E-selectin ligand expression in colon cancer cells undergoing EGF/bFGF-induced epithelial-mesenchymal transition

• DOI: 10.1073/pnas.1111135109
• 发表时间: 2012-05-15
• 期刊: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
• 影响因子: 11.1
• 作者: Sakuma, Keiichiro;Aoki, Masahiro;Kannagi, Reiji
• 通讯作者: Kannagi, Reiji

Induction of 6-sulfated glycans with cell adhesion activity via T-bet and GATA-3 in human helper T cells

通过 T-bet 和 GATA-3 在人类辅助 T 细胞中诱导具有细胞粘附活性的 6-硫酸化聚糖

• DOI: 10.1016/j.bbagen.2012.03.005
• 发表时间: 2012
• 期刊: Biochim Biophys Acta
• 作者: Sakuma K;Chen GY;Aoki M;Kannagi R.
• 通讯作者: Kannagi R.

EGF and bFGF induce EMT and E-selectin ligandglycan expression on colorectal cancer cells

EGF和bFGF诱导结直肠癌细胞上EMT和E-选择素配体聚糖的表达

• 发表时间: 2011
• 作者: 佐久間圭一朗;青木正博;神奈木玲児
• 通讯作者: 神奈木玲児

Th2-specific homing ligands involved in recurrent atopic dermatitis exacerbations

Th2特异性归巢配体参与复发性特应性皮炎恶化

• 发表时间: 2011
• 作者: Kannagi;R.;Ohmori;K.;Chen;G. Y.;Miyazaki;K.;Izawa;M.;and Sakuma;K.;佐久間圭一朗
• 通讯作者: 佐久間圭一朗