High quality cardiopulmonary-brain resuscitation with antioxidant administration just before starting resuscitation (Animal study)

我们设计了脑缺血再灌注动物（大鼠）模型，模拟了植物人心肺骤停复苏后血液氧化和抗氧化状态。在该模型中，再灌注前给予维生素C 10mg和20mg/体可抑制再灌注后血浆活性氧代谢物的增加，再灌注前给予维生素C 20mg/体可增加血浆生物抗氧化潜能。

We devised brain ischemia and reperfusion animal (rat) model analogous to blood oxidative and anti-oxidative states observed in Vegetative State patients after cardiac and pulmonary arrest and resuscitation. In this model, Vitamin C 10mg and 20mg/body administrations just before reperfusion suppressed the increase of plasma reactive oxygen metabolites after the reperfusion and Vitamin C 20mg/body administration just before reperfusion increased the plasma biological antioxidant potential.