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Pathophysiological analysis of third degree burn and efficacy of total escharectomy in super early phase of burn injury

三度烧伤病理生理分析及烧伤超早期全焦痂切除术的疗效

基本信息

批准号：
04670750
负责人：
SHINOZAWA Yotaro
金额：
$ 1.41万
依托单位：
Keio University
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (C)
财政年份：
1992
资助国家：
日本
起止时间：
1992 至 1994
项目状态：
已结题

项目摘要

The efficacies of super early phase total escharectomy and mediator modulation on survival rate and oxygen radical product, which was considered to associate with organ dysfunction, were studied. 1.Effect of super early phase total escharectomy on survival rate Survival rates were as followed ; 43% (3/7) in non-escharectomy, 25% (1/4) in escharectomy alone, 50% (1/2) in escharectomy and allograft and 100% (2/2) in escharectomy and direct suture closure. Super early phase escharectomy did not expand the life span of 30% third degree burn rats, unless the excisioned wound was not properly managed. 2.Effect of super early phase total escharectomy and mediator modulation oxygen radical product Plasma malondialdehyde (MDA) level at two hours after burn was not changed by super early phase total escharectomy. Mediator modulation by aspirin (50,100,200 mg/kg) intra peritoneal administration immediately after burn lowered the plasma MDA levels in any dose aspirin administration groups. 3.Effec … More t of super early phase total escharectomy and mediator modulation on eicosanoidsSuper early phase total escharectomy lowered plasma levels of thromboxane (Tx) B2 and 6keto prostaglandin (PG) F1 alpha, and aspirin lowered TxB2 levels in dependence on administered aspirin dose. TxB2/6ketoPGF1 alpha ratio was lowest in 50 mg/kg aspirin administered group, and this ratio was lower in total escharectomy subgroup compared with that in non-eschaectomy subgroup in 0,100,200 mg/kg aspirin administered groups.Conclusion ; 1.Super early phase total escharectomy in 30% third degree burn reduced vasoconstrictive and platelet aggregative mediator TxA2 production, and 50 mg/kg intra peritoneal administration of aspirin lowered TxA2/PGI2 ratio. PGI2 serves for vasodilatation and inhibits platelet aggregation. So super early phase total escharectomy and mediator modulation by 50 mg/kg administration of aspirin were considered useful to maintain the microcirculation in animal with deep degree burn. 2.For the better prognosis in super early phase escharectomy group, proper wound care for excised burned wound was considered inevitable. Less

研究了超早期全焦痂切除术和介质调节对存活率和氧自由基产物（被认为与器官功能障碍相关）的功效。 1.超早期全切痂对生存率的影响生存率如下；非切痂术为 43% (3/7)，单纯切痂术为 25% (1/4)，切痂术和同种异体移植术为 50% (1/2)，切痂术和直接缝合闭合术为 100% (2/2)。超早期切痂并不能延长30%三度烧伤大鼠的寿命，除非切除的伤口处理不当。 2.超早期全切痂及介质调节氧自由基产物的作用超早期全切痂未改变烧伤后2小时血浆丙二醛(MDA)水平。烧伤后立即腹膜内施用阿司匹林（50,100,200 mg/kg）进行介质调节，可降低任何剂量阿司匹林施用组的血浆MDA水平。 3.超早期全焦痂切除术和类花生酸介导调节的效果超早期全焦痂切除术降低了血栓素 (Tx) B2 和 6 酮前列腺素 (PG) F1 α 的血浆水平，而阿司匹林则根据阿司匹林给药剂量降低了 TxB2 水平。 50mg/kg阿司匹林给药组中TxB2/6ketoPGF1α比值最低，且0,100,200mg/kg阿司匹林给药组中全切痂亚组的该比值低于非切痂亚组。 1.30%三度烧伤的超早期全切痂减少了血管收缩和血小板聚集介质TxA2的产生，腹腔注射50 mg/kg阿司匹林降低了TxA2/PGI2比值。 PGI2 具有血管舒张作用并抑制血小板聚集。因此，超早期全切痂和50 mg/kg阿司匹林调节介质被认为有助于维持深度烧伤动物的微循环。 2.为了使超早期切痂组有更好的预后，对切除的烧伤创面进行适当的伤口护理是不可避免的。较少的