The elucidation of the aging promotion mechanism by FEN1 control

我们发现抑制FEN1导致人膀胱癌细胞株T24和人成纤维细胞系BJ衰老。在这种情况下，细胞周期相关基因的表达，DNA损伤反应，以及DNA的不稳定状态被引起。另一方面，我们认识到FEN1与参与衰老的端粒结合，并与端粒损伤反应有关。此外，提示在FEN1抑制衰老过程中，存在P53依赖和P53非依赖两种方式。

We identified that FEN1 inhibition lead to senescence in human bladder cancer cell line T24 and human fibroblast cell line BJ. On this occasion, expression of cell cycle related genes, DNA damage response, and unstable condition of DNA was caused. On the other hand, we recognized that FEN1 is binding to telomere involved in senescence, and related to telomere damage response. Furthermore, it was suggestedthat on senescence by FEN1 inhibition, there are p53-dependent and p53-independent manner.