Autoimmune Disease of FEN1 Transgenic Mouse

FEN1转基因小鼠的自身免疫性疾病

• 批准号: 20592204
• 负责人: KIMURA Yasuo
• 金额: $ 3万
• 依托单位: Nagasaki University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20592204/
• 关键词: FEN1; 自己免疫疾患; MRI; 拡散強調撮像; IQIマウス; ERストレス; XBP=1

I performed various examination in FEN1 transgenic mouse, but was not able to confirm it whether autoimmune disease developed. I confirmed the lymphocyte permeation of the salivary gland (submandibular gland, sublingual gland) in the IQI mouse which was a mouse of the autoimmune disease instead. However, it was difficult to confirm a meaningful difference between a normal mouse by MR imaging (diffusion emphasis imaging) about the minute change of these salivary glands.

我在FEN1转基因小鼠中进行了各种检查，但无法确认自身免疫性疾病是否发展。我证实了IQI小鼠中唾液腺（下颌下腺，舌下腺）的淋巴细胞渗透，这是自身免疫性疾病的小鼠。但是，很难通过通过MR成像（扩散强调成像）在这些唾液腺的分钟变化之间证实正常小鼠之间的有意义的差异。