Dental cements containing sericin powder with cell biological properties show effect of wound healing

含有具有细胞生物学特性的丝胶粉的牙科水泥显示出伤口愈合作用

• 批准号: 22592186
• 负责人: YOSHIDA Keiichi
• 金额: $ 2.91万
• 依托单位: Nagasaki University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22592186/
• 关键词: セリシン; 生体材料学; レジンセメント; コンポジットレジン; ヌープ硬さ; 創傷治癒; 細胞生物学; 歯科用セメント

Sericin powder was added in a commercially available self-adhesive resin cement or resin-modified glass ionomer cement with various concentrations. Specimens were measured Knoop hardness from directly after specimen preparation to long-term immersion in distilled water. As a result, it was revealed that the hardening properties were equal to additive-free control when it was added 5.0% by weight in both resin cements.In addition, after crown preparation of the rat maxillary central incisor, temporary crownswere sealed with commercially available resin-modified glass ionomer cement containing sericin 5.0% by weight. As a result, the recovery of inflammation of a cornification epithelium and the attached gingiva seated the temporary crown with sericin-containing resin-modified glass ionomer cement was equivalent to healthy gingival control group after 3-months provisional cementation. The wound healing effect was not shown enough.

将丝胶粉末按不同浓度添加到市售的自粘性树脂粘固剂或树脂改性玻璃离子粘固剂中。从试件制备后到长期浸泡在蒸馏水中，测量试件的诺氏硬度。结果表明，在两种树脂粘固剂中分别加入5.0%的丝胶粘固剂时，其硬化性能相当于无添加剂的对照。此外，在大鼠上中切牙的冠预备后，用市售的丝胶含量为5.0%的树脂改性玻璃离子粘固剂封闭临时冠。结果：临时粘接3个月后，角化上皮炎症和附着在临时冠上的牙周炎的恢复情况与健康牙龈对照组相当。创面愈合效果不够明显。