Elucidation of cerebral protection of lidocaine with transient corticalischemia/reperfusion model

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Reduction of infarct size was confirmed in comparison with the control group 5 days after 30 min middle cerebral artery occlusion (MCAO) and reperfusion by administering lidocaine before MCAO. Expression of Caspase3 in infarct area was observed slightly in both lidocaine and control group by immunohistochemical staining, but there was not difference between the two groups. Nestin-positive neural stem cells were expressed around microvasculature in the infarct area and penumbra region. It was suggested that nestin-positive neural stem cells were often observed as a cause of the infarct zone reduced by pharmacological preconditioning of lidocaine, enhancement of nerve regeneration wit that is different from the reactive glial cells.