Elucidation of cerebral protection of lidocaine with transient corticalischemia/reperfusion model

阐明利多卡因对短暂性皮质缺血/再灌注模型的脑保护作用

• 批准号: 22592271
• 负责人: MOMOTA Yoshihiro
• 金额: $ 2.75万
• 依托单位: Osaka Dental University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22592271/
• 关键词: 脳,神経; 脳神経疾患; 神経科学; 再生医学; 脳・神経; 歯学

Reduction of infarct size was confirmed in comparison with the control group 5 days after 30 min middle cerebral artery occlusion (MCAO) and reperfusion by administering lidocaine before MCAO. Expression of Caspase3 in infarct area was observed slightly in both lidocaine and control group by immunohistochemical staining, but there was not difference between the two groups. Nestin-positive neural stem cells were expressed around microvasculature in the infarct area and penumbra region. It was suggested that nestin-positive neural stem cells were often observed as a cause of the infarct zone reduced by pharmacological preconditioning of lidocaine, enhancement of nerve regeneration wit that is different from the reactive glial cells.

大脑中动脉闭塞（MCAO）30分钟后5天，通过在MCAO之前施用利多卡因再灌注，与对照组相比，证实梗塞面积减少。免疫组化染色显示利多卡因组和对照组梗死区均有轻微的Caspase3表达，但两组之间无差异。巢蛋白阳性神经干细胞在梗死区和半影区的微血管周围表达。有人提出，巢蛋白阳性神经干细胞经常被观察为利多卡因药理预处理减少梗塞区的原因，与反应性神经胶质细胞不同，神经再生能力增强。

项目成果

Expression of transient cortical ischemia induced neural stem/progenitor cells in mice.

短暂皮质缺血诱导小鼠神经干/祖细胞的表达。

• 发表时间: 2012
• 作者: Kajii TS;Sato Y;Iida J;Momota Y.
• 通讯作者: Momota Y.

Changes in blood pressure during induction of anesthesia and oral and maxillofacial surgery by type and timing of discontinuation of antihypertensive drugs.

• DOI: 10.2344/0003-3006-57.1.13
• 发表时间: 2010-01-01
• 期刊: Anesthesia progress
• 作者: Momota, Yoshihiro;Kaneda, Kazuhiro;Kotani, Junichiro
• 通讯作者: Kotani, Junichiro

一過性脳虚血により誘導されるペリサイト由来神経幹細胞の発現

短暂性脑缺血诱导周细胞源性神经干细胞的表达

• 发表时间: 2012
• 作者: Chong Huat Siar;et.al.;百田義弘
• 通讯作者: 百田義弘

脱分化脂肪細胞と自己組織化ペプチドRADA16を用いた骨組織再生の検討

使用去分化脂肪细胞和自组装肽 RADA16 检查骨组织再生

• 发表时间: 2011
• 作者: Tomonori Sasahira;Ujjal K. Bhawal;Miyako Kurihara;Nobuhiro Ueda;Kazuhiko Yamamoto;Tadaaki Kirita;Hiroki Kuniyasu;Adachi K;岸本直隆
• 通讯作者: 岸本直隆

ヒト脱分化脂肪細胞は脂肪幹細胞より骨芽細胞分化能が高い

人去分化脂肪细胞比脂肪干细胞具有更高的成骨细胞分化潜力

• 发表时间: 2012
• 作者: 岸本直隆;百田義弘;橋本典也;安東佳代子;坂本章人;大政健史;小谷順一郎
• 通讯作者: 小谷順一郎