Development and the clinical application of the bioabsorbed mesh onplant system for orthodontic anchorage

本研究旨在研制一种新型的生物可吸收网片种植支抗系统。将牛牙本质脱矿基质（DDM）移植于大鼠颅骨缺损区，观察其骨再生能力及作为生物可吸收网状植骨系统骨替代物的可能性。总之，DDM可能是一种有用的骨替代物，可作为骨再生的支架，在手术后不久诱导高水平的新骨形成。第二项研究的目的是确定Reveromucin A（RMA）抑制OPG-/-小鼠骨吸收的作用。这些数据表明，RMA使OPG-/-小鼠在连续牙齿移动过程中的骨代谢和牙槽骨丢失正常化，因此本研究认为RMA具有生物可吸收网状种植系统的可能性。

The purpose of this study is to development new bioabsorbed mesh onplant system for orthodontic anchorage. Demineralized dentin matrix (DDM), an organic material derived from the dentine of bovine teeth, was grafted in rat skull defects to determine its bone regeneration ability and the possibility of its use as a bone substitute for bioabsorbed mesh onplant system. In conclusion, DDM may be a useful bone substitute that serves as a scaffold for bone regeneration by inducing a high level of new bone formation soon after surgery. The purpose of the second study was to identify the effect of Reveromucin A (RMA) on inhibiting bone resorption in OPG-/- mice. These data was suggested that RMA normalizes bone metabolism and loss of alveolar bone during continuous tooth movement in OPG-/- mice.This study concluded that RMA has possibility of the bioabsorbed mesh onplant system.