Categorization of the bacterial non-coding RNAs and development of the custom array

为了开发用于牙周病诊断的定制阵列以预测牙周病的风险，我们将细菌小的非编码rna作为诊断探针的新靶点，因为它们与细菌的致病表达相关且难以分解。用下一代DNA测序仪对牙龈假单胞菌表达的rna进行环状分析。包括预测的非编码RNA在内，在纤毛中可以确认的RNA有数百种。它们将在未来被用作微阵列探针。

For the purpose of development of the custom array for diagnoses to predict a risk of the periodontal disease, we paid attention the bacteria small non-coding RNAs as new targets of the diagnosis probes because they are associated with the bacterial pathogenic expressions and are hard to be disintegrated. Expressed RNAs in P. gingivalis were analyzed by a next - generation DNA sequencer cyclopedically. Several hundred kinds could be confirmed including predicted non-coding RNA in cilico. They are going to be utilizedas microarrays probe in future.