Basic research on the influence of obesity, menopause, lymphatics, and honey on the clean healing of full-thickness cutaneous wounds

我们研究了影响小鼠全层皮肤创伤愈合的因素。雌激素对去卵巢小鼠的伤口愈合有促进作用，而对雄性小鼠无促进作用。至于它是否只对女性有效，还有进一步调查的余地。异黄酮对创面愈合的影响尚不清楚。目前还不清楚肥胖是否会导致伤口愈合延迟，因为肥胖的老鼠在受伤后体重急剧下降。因此，有必要重新审视肥胖模型。抑制淋巴管生成似乎延迟了愈合。由于蜂蜜对伤口或烧伤伤口的作用取决于蜂蜜的种类，因此有必要对几种蜂蜜进行评估。

We investigated factors that affect the healing of full-thickness cutaneous wounds in mice. Estrogen was effective for wound healing in ovariectomized mouse, but not in male mouse. There is room for further investigation on whether it is effective only in females. The effect of isoflavone on wound healing was not clear. It was also unclear whether obesity caused a delay of wound healing because the obese mice dramatically lost weight after wounding. It is thus necessary to re-examine models of obesity. Inhibition of lymphangiogenesis seemed to delay the healing. Since the effect of honey on wounds or burn wounds depended on the type of honey, it is necessary to evaluate several kinds of honey.