Establishment of a new strategy for the treatment of spinal cord injury: Intrathecal administration of incubated autologous bone marrow stromal cells.

建立治疗脊髓损伤的新策略：鞘内施用孵育的自体骨髓基质细胞。

• 批准号: 23390414
• 负责人: NAKATANI Toshio
• 金额: $ 8.07万
• 依托单位: Kansai Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23390414/
• 关键词: 脊髄損傷; 脊髄再生; 骨髄単核球; 髄液内投与; 骨髄間質細胞; 四肢麻痺; 対麻痺; 運動スコア; 知覚スコア; AIS grade; 単核球; 幹細胞

To determine whether intrathecal administration of autologous bone marrow cells is safe and feasible for treatment of subacute spinal injury, five patients with tetraplegia due to cervical spinal injury and 5 with paraplegia due to thoracic spinal injury were included. About 1 million mononuclear cells were obtained from their own iliac bone, and administered immediately into cerebrospinal fluid by lumbar puncture. The patients were closely observed for 6 months. No adverse responses were observed. In a few patients treated earlier, definite motor and sensory recovery was remarkable, but limited in patients treated later. Spinal injury treatment with administration of bone marrow cells into cerebrospinal fluid is safe and feasible underwent in the early subacute phase.

为了确定鞘内注射自体骨髓细胞治疗亚急性脊髓损伤是否安全可行，纳入了5例颈椎损伤所致四肢瘫和5例胸椎损伤所致截瘫患者。从他们自己的髂骨获得约100万个单核细胞，并通过腰椎穿刺立即注入脑脊液。密切观察6个月。未观察到不良反应。在少数早期治疗的患者中，明确的运动和感觉恢复是显著的，但在后期治疗的患者中有限。在脊髓损伤的亚急性期，脑脊液内注入骨髓细胞是安全可行的。

项目成果

Asian Congress of Neurological Surgeons

亚洲神经外科医生大会

• 发表时间: 2011
• 作者: Iwase M;Nakatani T;Saito F;et al
• 通讯作者: et al

当院における脊髄損傷に対する再生医療への取り組み

我院针对脊髓损伤的再生医学举措

• 作者: Nakatani Toshio;Iwase Masaaki;Saito Fukuki;Ikedo Taichi;Omura Tomohisa;Tsuchiya Hiroyuki;Maeda Yuji;Hirakawa Akihiko;Murao Yoshinori;Matsumoto Kenji;Sakamoto Tomosaburo;Iiji Satoshi;Suzuki Yoshihisa;Fukushima Masanori;Ide Chizuka;齊藤福樹;齊藤福樹
• 通讯作者: 齊藤福樹

Intrathecal administration of bone marrow mononuclear cells for the treatment of spinal injury; a clinical trial

鞘内注射骨髓单核细胞治疗脊髓损伤；

• 发表时间: 2013
• 作者: Toshio Nakatani;Fukuki Saito;Yoshimasa Suzuki;Masanori Fukushima;Chizuka Ide
• 通讯作者: Chizuka Ide

Bone marrow-derived mononuclear cell transplantation in spinal cord injury patients by lumbar puncture

• DOI: 10.3233/rnn-130363
• 发表时间: 2014-01-01
• 期刊: RESTORATIVE NEUROLOGY AND NEUROSCIENCE
• 影响因子: 2.8
• 作者: Suzuki, Yoshihisa;Ishikawa, Namiko;Ide, Chizuka
• 通讯作者: Ide, Chizuka

骨髄間質細胞

骨髓基质细胞

• 发表时间: 2011
• 期刊: Bone Joint Nerve
• 作者: Fukuki Saito;Toshio Nakatani;Masaaki Iwase;Yuji Maeda;Yoshinori Murao;Yoshihisa Suzuki;Masanori Fukushima;Chizuka Ide;T. Maeda;今待賢治;中谷壽男
• 通讯作者: 中谷壽男