Synthesis of the bioactive fluorescent molecules: (inspired by pluramycins)

研究了多柔比星全合成的合成路线。开发了合成双-C-糖苷和苷元的有效方法。这些方法被成功地应用于多菌素中的一种皂霉素B的全合成。该合成路线可作为合成多柔比星衍生物和化学生物学研究的基础技术。

Development of synthetic route to the total synthesis of pluramycins, was studied. The efficient ways for the bis-C-glycoside and aglycon synthesis were developed. These methodologies were successfully applied to the total synthesis of the saptomycin B, which is one of the pluramycins. This synthetic route would be expanded as a fundamental technology to the synthesis of pluramycin derivatives and the studies of chemicalbiology.