Synthesis of the bioactive fluorescent molecules: (inspired by pluramycins)

研究了普朗霉素全合成路线的发展。发展了双碳苷和苷元的高效合成方法。这些方法已成功地应用于普拉霉素之一的沙普霉素B的全合成。该合成路线可作为基础技术拓展到普朗霉素衍生物的合成及化学生物学研究中。

Development of synthetic route to the total synthesis of pluramycins, was studied. The efficient ways for the bis-C-glycoside and aglycon synthesis were developed. These methodologies were successfully applied to the total synthesis of the saptomycin B, which is one of the pluramycins. This synthetic route would be expanded as a fundamental technology to the synthesis of pluramycin derivatives and the studies of chemicalbiology.