Research for factors in everyday life augmenting virus in saliva

日常生活中增加唾液中病毒的因素的研究

• 批准号: 22650158
• 负责人: ARAO Yujiro
• 金额: $ 2.04万
• 依托单位: Okayama University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22650158/
• 关键词: 保健健康情報; 持続感染ウイルス; 核酸; ヒトヘルペスウイルス6型; トルケテノウイルス; 感染症; ストレス; 微生物; ウイルス; 遺伝子増幅

To prevent healthy persons from onset and deterioration of viral disease, we need to know unknown factors in everyday life increasing virus load in them. The aim of this study is to find such factors by utilizing viruses that is persistently infecting healthy persons and excreted into saliva. I found that practical training in a hospital, job hunting, listening unfavorable music, and reduced sleeping hours significantly heightened the human herpesvirus type 6(HHV6)-positive rate of saliva samples(p<0. 05). I also found that the factors induced the similar increase in the torque teno virus(TTV)-positive rate of saliva samples but the increase was not significant. Sleeping hours also correlated reversely with the TTV-positive rate(r=-0. 71), suggesting that reduction in sleeping hours is an enhancive factor for TTV in saliva in addition to HHV6.

为了预防健康人的病毒性疾病的发病和恶化，我们需要了解日常生活中增加病毒载量的未知因素。这项研究的目的是通过利用持续感染健康人并排泄到唾液中的病毒来寻找这些因素。我发现，在医院接受实践培训、找工作、听不好的音乐、减少睡眠时间，都会显著提高唾液样本中人类疱疹病毒6型(HHV6)的阳性比率(p&lt；0。05)。我还发现，这些因素导致的扭矩Teno病毒(TTV)阳性率在唾液样本中也有类似的增加，但增加不明显。睡眠时间与TTV阳性率呈负相关(r=-0。71)，这表明除了HHV6外，睡眠时间的减少也是唾液中TTV的一个促进因素。