Expressional and regulatory characterization of mRNA and miRNA for food-intake related molecules

食物摄入相关分子 mRNA 和 miRNA 的表达和调控特征

• 批准号: 22650179
• 负责人: MATSUDA Satoru
• 金额: $ 2.12万
• 依托单位: Nara Women's University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22650179/
• 关键词: 健康と食生活; 遺伝子発現; 細胞内シグナル伝達; 摂食ホルモン; 食健康; 遺伝子; 発現制御; 生理活性; 食品成分; 食品

Some of herbs and spices have shown potential in preventing the occurrence and/or progression of cancer and other chronic diseases including anorexia. They are being screened to explore the possibility of development of feasible medical drugs by analyzing the expression of mRNA and miRNA. For example, mRNA and protein expression levels of AKT1 were reduced compared with the control cells 48 hours after these herbal treatments in cells treated with sage or rosemary extract.

一些草药和香料已显示出预防癌症和其他慢性疾病（包括厌食症）的发生和/或进展的潜力。目前正在对它们进行筛选，以通过分析mRNA和miRNA的表达来探索开发可行的医疗药物的可能性。例如，在用鼠尾草或迷迭香提取物处理的细胞中，在这些草药处理后48小时，与对照细胞相比，AKT 1的mRNA和蛋白质表达水平降低。

项目成果

PI3K/AKT/PTEN Signaling as a Molecular Target in Leukemia Angiogenesis.

• DOI: 10.1155/2012/843085
• 发表时间: 2012
• 期刊: Advances in hematology
• 作者: Okumura N;Yoshida H;Kitagishi Y;Murakami M;Nishimura Y;Matsuda S
• 通讯作者: Matsuda S

Turmeric and curcumin repressed presenilin1 protein expression in Jurkat cells.

姜黄和姜黄素抑制 Jurkat 细胞中早老素 1 蛋白的表达。

• 发表时间: 2011
• 期刊: Experimental and Therapeutic Medicine
• 影响因子: 2.7
• 作者: H. Yoshida;N. Okumura;Y. Kitagishi;Y. Nishimura;S. Matsuda
• 通讯作者: S. Matsuda

Ethanol extract of Rosemary repressed PTEN expression in K562 culture cells.

迷迭香乙醇提取物抑制 K562 培养细胞中 PTEN 的表达。

• 发表时间: 2011
• 期刊: Int J appl Biol pharm Technol
• 作者: Matsuda S;Yoshida H;et al.
• 通讯作者: et al.

Roles for PI3K/AKT/PTEN Pathway in Cell Signaling of Nonalcoholic Fatty Liver Disease.

• DOI: 10.1155/2013/472432
• 发表时间: 2013
• 期刊: ISRN endocrinology
• 作者: Matsuda S;Kobayashi M;Kitagishi Y
• 通讯作者: Kitagishi Y

Defective DNA repair systems and the development of breast and prostate cancer.

DNA 修复系统缺陷与乳腺癌和前列腺癌的发生。

• 发表时间: 2012
• 期刊: Int J Oncol
• 影响因子: 5.2
• 作者: Y. Kitagishi;M. Kobayashi;S. Matsuda
• 通讯作者: S. Matsuda