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Expressional and regulatory characterization of mRNA and miRNA for food-intake related molecules

Expressional and regulatory characterization of mRNA and miRNA for food-intake related molecules
食物摄入相关分子 mRNA 和 miRNA 的表达和调控特征
批准号:
22650179
负责人:
MATSUDA Satoru
金额:
$2.12万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Challenging Exploratory Research
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2012

项目摘要

项目成果

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中文摘要
翻译
一些草药和香料在预防癌症和其他慢性疾病(包括厌食症)的发生和/或进展方面显示出潜力。通过分析mRNA和miRNA的表达,对它们进行筛选,以探索开发可行药物的可能性。例如,用鼠尾草或迷迭香提取物处理的细胞在这些草药处理48小时后,与对照细胞相比,AKT1的mRNA和蛋白质表达水平降低。
英文摘要
Some of herbs and spices have shown potential in preventing the occurrence and/or progression of cancer and other chronic diseases including anorexia. They are being screened to explore the possibility of development of feasible medical drugs by analyzing the expression of mRNA and miRNA. For example, mRNA and protein expression levels of AKT1 were reduced compared with the control cells 48 hours after these herbal treatments in cells treated with sage or rosemary extract.
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会议论文
DOI: 10.1155/2012/843085
发表时间: 2012
期刊: Advances in hematology
影响因子: --
作者: [Okumura N, Yoshida H, Kitagishi Y, Murakami M, Nishimura Y, Matsuda S]
通讯作者: Matsuda S
Turmeric and curcumin repressed presenilin1 protein expression in Jurkat cells.
姜黄和姜黄素抑制 Jurkat 细胞中早老素 1 蛋白的表达。
DOI: --
发表时间: 2011
期刊: Experimental and Therapeutic Medicine
影响因子: 2.7
作者: [H. Yoshida, N. Okumura, Y. Kitagishi, Y. Nishimura, S. Matsuda]
通讯作者: S. Matsuda
Ethanol extract of Rosemary repressed PTEN expression in K562 culture cells.
迷迭香乙醇提取物抑制 K562 培养细胞中 PTEN 的表达。
DOI: --
发表时间: 2011
期刊: Int J appl Biol pharm Technol
影响因子: --
作者: [Matsuda S, Yoshida H, et al.]
通讯作者: et al.
DOI: 10.1155/2013/472432
发表时间: 2013
期刊: ISRN endocrinology
影响因子: --
作者: [Matsuda S, Kobayashi M, Kitagishi Y]
通讯作者: Kitagishi Y
Exploring the drug resistance mechanism through cellular senescence in the tumor microenvironment in esophageal cancer
  • 批准号:
    19K23924
  • 项目类别:
    Grant-in-Aid for Research Activity Start-up
  • 资助金额:
    $1.83万
  • 财政年份:
    2019
  • 负责人:
    MATSUDA Satoru
  • 依托单位:
Diets may contribute to the improved cellular function via the modulation of AKT signaling
  • 批准号:
    25560050
  • 项目类别:
    Grant-in-Aid for Challenging Exploratory Research
  • 资助金额:
    $2.41万
  • 财政年份:
    2013
  • 负责人:
    MATSUDA Satoru
  • 依托单位:
Interaction of DNA repair epigenetics and Nutrition
  • 批准号:
    24240098
  • 项目类别:
    Grant-in-Aid for Scientific Research (A)
  • 资助金额:
    $30.37万
  • 财政年份:
    2012
  • 负责人:
    MATSUDA Satoru
  • 依托单位:
Analysis of prion and prion related protein for the purpose of food safety
  • 批准号:
    19300251
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
  • 资助金额:
    $11.73万
  • 财政年份:
    2007
  • 负责人:
    MATSUDA Satoru
  • 依托单位:
海外基金