Hierarchical Study on Protein Functional Mechanism

在生物分子作用机理的一般蛋白质工程研究中，使用湿材料的实验和使用干式计算机的信息学是独立进行的。然而，要突破对蛋白质功能机制的理解，必须将实验和信息学方法协同结合起来。本研究以噬菌体展示法为实验手段，以优化方法为信息学手段，发现了新型短肽和一种小分子化合物能够抑制淀粉样蛋白β的纤颤和可溶性低聚物的形成。

In general protein engineering studies for functional mechanism of biomolecules, experiments using wet materials and informatics using dry computers are independently performed. However, it will be necessary for breakthrough of understanding of protein functional mechanisms to combine the experiments with the informatics methods synergistically. In this study, by using a phage display method as an experiment and an optimization method as informatics, novel short peptides and a small compound were found to inhibit fibrillation and soluble oligomer formation of amyloidβprotein.