Role of fatty acid-binding protein in the brain vulnerability in schizophrenia

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H-FABP is associated with D2L receptor in vivo. H-FABP null mice showed increased anxiety and impaired cognitive behavior. The impaired cognitive behavior was associated with decreased CaMKII activities in the cingulate cortex and DHA diet improved the impaired cognitive behaviors in H-FABP null mice. Thus, the decreased CaMKII activity likely mediates impairments of cognitive function in H-FABP null mice. H-FABP null mice are useful to define the role of FABP in the vulnerable of schizophrenia brain.