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Development of novel analytical methods of nucleotide sugars with the aim of monitoring tumor microenvironment

Development of novel analytical methods of nucleotide sugars with the aim of monitoring tumor microenvironment
开发新的核苷酸糖分析方法以监测肿瘤微环境
批准号:
22659067
负责人:
NAKAJIMA Kazuki
金额:
$1.98万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Challenging Exploratory Research
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2011

项目摘要

项目成果

NAKAJIMA Kazuki的其他基金

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相关文献

中文摘要
翻译
我们已经开发了两种色谱方法来监测细胞内核苷酸糖及其代谢途径,以阐明核苷酸糖在肿瘤微环境中的生理意义。我们检查了癌细胞系中葡萄糖剥夺和缺氧条件下核苷酸糖的变化,发现仅胰腺癌细胞系中UDP-GlcNAc和UDP-Gal的特异性减少影响细胞N-聚糖结构。
英文摘要
We have developed two chromatographic methods for monitoring intracellular nucleotide sugars and their metabolic pathway, to clarify the physiological significance of nucleotide sugars in tumor microenvironments. We examined the changes of nucleotide sugars by glucose deprivation and hypoxic conditions in cancer cell lines, and found that specific reduction of UDP-GlcNAc and UDP-Gal in only pancreatic cancer cell lines influences cellular N-glycan structures.
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会议论文
UDP-GlcNAc代謝物の新規解析戦略-糖代謝異常における糖ヌクレオチドの関与-
UDP-GlcNAc 代谢物的新分析策略 - 糖核苷酸参与异常葡萄糖代谢 -
DOI: --
发表时间: 2011
期刊:
影响因子: --
作者: [中嶋和紀, 白土健, 大坪和明, 高宮里奈, 北爪しのぶ, 安形高志, 谷口直之]
通讯作者: 谷口直之
Strategy for dynamic tracing of UDP-GlcNAc Metabolism
UDP-GlcNAc 代谢动态追踪策略
DOI: --
发表时间: 2011
期刊:
影响因子: --
作者: [Nakajima K, et al.(他6名)]
通讯作者: et al.(他6名)
Tracing strategy of UDP-GlcNAc metabolism by mass isotopomers analysis-Specific sialic acid biosynthesis in pancreatic beta cells-
通过质量同位素分析追踪UDP-GlcNAc代谢的策略-胰腺β细胞中特异性唾液酸生物合成-
DOI: --
发表时间: 2011
期刊:
影响因子: --
作者: [Nakajima K, Shirato K, Ohtsubo K, Takamiya R, Kitazume S, Angata T, and Taniguchi N]
通讯作者: and Taniguchi N
DOI: 10.1007/s11064-012-0735-z
发表时间: 2012-06-01
期刊: NEUROCHEMICAL RESEARCH
影响因子: 4.4
作者: [Ito, Emi, Tominaga, Akio, Suzuki, Akemi]
通讯作者: Suzuki, Akemi
14
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