Development of novel analytical methods of nucleotide sugars with the aim of monitoring tumor microenvironment
Development of novel analytical methods of nucleotide sugars with the aim of monitoring tumor microenvironment
批准号:
22659067
负责人:
NAKAJIMA Kazuki
金额:
$1.98万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Challenging Exploratory Research
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2011
中文摘要
我们已经开发了两种色谱方法来监测细胞内核苷酸糖及其代谢途径,以阐明核苷酸糖在肿瘤微环境中的生理意义。我们检查了癌细胞系中葡萄糖剥夺和缺氧条件下核苷酸糖的变化,发现仅胰腺癌细胞系中UDP-GlcNAc和UDP-Gal的特异性减少影响细胞N-聚糖结构。
英文摘要
We have developed two chromatographic methods for monitoring intracellular nucleotide sugars and their metabolic pathway, to clarify the physiological significance of nucleotide sugars in tumor microenvironments. We examined the changes of nucleotide sugars by glucose deprivation and hypoxic conditions in cancer cell lines, and found that specific reduction of UDP-GlcNAc and UDP-Gal in only pancreatic cancer cell lines influences cellular N-glycan structures.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
登录
查看更多内容
UDP-GlcNAc代謝物の新規解析戦略-糖代謝異常における糖ヌクレオチドの関与-
UDP-GlcNAc 代谢物的新分析策略 - 糖核苷酸参与异常葡萄糖代谢 -
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[中嶋和紀, 白土健, 大坪和明, 高宮里奈, 北爪しのぶ, 安形高志, 谷口直之]
通讯作者:
谷口直之
Strategy for dynamic tracing of UDP-GlcNAc Metabolism
UDP-GlcNAc 代谢动态追踪策略
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Nakajima K, et al.(他6名)]
通讯作者:
et al.(他6名)
Tracing strategy of UDP-GlcNAc metabolism by mass isotopomers analysis-Specific sialic acid biosynthesis in pancreatic beta cells-
通过质量同位素分析追踪UDP-GlcNAc代谢的策略-胰腺β细胞中特异性唾液酸生物合成-
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Nakajima K, Shirato K, Ohtsubo K, Takamiya R, Kitazume S, Angata T, and Taniguchi N]
通讯作者:
and Taniguchi N
DOI:
10.1007/s11064-012-0735-z
发表时间:
2012-06-01
期刊:
NEUROCHEMICAL RESEARCH
影响因子:
4.4
作者:
[Ito, Emi, Tominaga, Akio, Suzuki, Akemi]
通讯作者:
Suzuki, Akemi
糖ヌクレオチド代謝物の新規解析法
糖核苷酸代谢物的新分析方法
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[中嶋和紀, 大坪和明, 高宮里奈, 白土健, 北爪しのぶ, 三善英知, 谷口直之]
通讯作者:
谷口直之
共 14 条
Development of a diaper cover that measures urine absorption for elderly dogs
-
批准号:16K12685
-
项目类别:Grant-in-Aid for Challenging Exploratory Research
-
资助金额:$2.25万
-
财政年份:2016
-
负责人:NAKAJIMA Kazuki
-
依托单位:
A Challenging Study of "Chameleon Printing" for Clothing for Wandering Prevention Assistance
-
批准号:15K15883
-
项目类别:Grant-in-Aid for Challenging Exploratory Research
-
资助金额:$2.33万
-
财政年份:2015
-
负责人:NAKAJIMA Kazuki
-
依托单位:
A challenge to a sensor development for detecting the presence or absence of excretion and the amount of it in a toilet seat
-
批准号:26671008
-
项目类别:Grant-in-Aid for Challenging Exploratory Research
-
资助金额:$2.33万
-
财政年份:2014
-
负责人:NAKAJIMA Kazuki
-
依托单位:
A challenging study on development of a device without being aware of sensors to detect the swallowing of food
-
批准号:25670992
-
项目类别:Grant-in-Aid for Challenging Exploratory Research
-
资助金额:$2.41万
-
财政年份:2013
-
负责人:NAKAJIMA Kazuki
-
依托单位:
High-speed and high-sensitive methods of carbohydrates based on mass isotopomer analysis with the aim of monitoring glycan dynamics
-
批准号:24790301
-
项目类别:Grant-in-Aid for Young Scientists (B)
-
资助金额:$2.83万
-
财政年份:2012
-
负责人:NAKAJIMA Kazuki
-
依托单位:
Grasp of home fixing state of patient with hemiplegia during discharging from hospital by using television operating state monitoring
-
批准号:22500501
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.75万
-
财政年份:2010
-
负责人:NAKAJIMA Kazuki
-
依托单位:
Development of a ubiquitous information technology system which realizes virtual living together with the aged family
-
批准号:19510143
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.91万
-
财政年份:2007
-
负责人:NAKAJIMA Kazuki
-
依托单位:
DEVELOPMENT OF EVALUATION SYSTEM BY IMAGE PROCESSING FOR BEDSORE PREVENTION AND TREATMENT WHICH CAN BE USED ON BEDSIDE
-
批准号:13672544
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.62万
-
财政年份:2001
-
负责人:NAKAJIMA Kazuki
-
依托单位:
海外基金