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adductome analysis of human tissues

adductome analysis of human tissues
人体组织加合组分析
批准号:
22659072
负责人:
SUGIMURA Haruhiko
金额:
$1.94万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Challenging Exploratory Research
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2011

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中文摘要
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英文摘要
High performance liquid chromatography and tandem mass spectrometry disclosed at least 10 lipid peroxidation related modified DNA bases in the DNAs extracted under anti-oxidation condition from human autopsy tissues. Among these 10 DNA adducts, 7 of them, 1, N6-etheno-2'-deoxyadenosine(εdA), butanone-etheno-2'-deoxycytidine(BεdC), butanone-etheno-2'-deoxy-5-methylcytidine(BεmedC), butanoneetheno-2'-deoxyadenosine(BεdA), heptanone-etheno-2'-deoxycytidine(HεdC), heptanone-etheno-2'-deoxyadenosine(HεdA), and heptanone-etheno-2'-deoxyguanosine(HεdG) were quantitated in gastric mucosa, resected for gastric cancer in Japan and China. The profiles of these DNA adducts identified the origin of the tissues(China or Japan), implying adductome profile may reflect environmental exposures of individual settings. We further tested the repair machinery against these modified bases and discovered TDG play s role in repairing some of these adducts.
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DOI: 10.1021/tx100047d
发表时间: 2010-09-01
期刊: CHEMICAL RESEARCH IN TOXICOLOGY
影响因子: 4.1
作者: [Chou, Pei-Hsin, Kageyama, Shinji, Matsuda, Tomonari]
通讯作者: Matsuda, Tomonari
DOI: 10.2133/dmpk.dmpk-11-sc-033
发表时间: 2011
期刊: Drug Metabolism and Pharmacokinetics
影响因子: 2.1
作者: [Tamaki, Y., Honda, M., Muroi, Y., Arai, T., Sugimura, H., Matsubara, Y., Kanno, S., Ishikawa, M., Hirasawa, N, Hiratsuka, M.]
通讯作者: M.
Adenine DNA glycosylase activity of 14 human MutY homolog (MUTYH) variant proteins found in patients with colorectal polyposis and cancer.
在结直肠息肉病和癌症患者中发现的 14 种人类 MutY 同源物 (MUTYH) 变异蛋白的腺嘌呤 DNA 糖基化酶活性。
DOI: 10.1002/humu.21363
发表时间: 2010-11
期刊: HUMAN MUTATION
影响因子: 3.9
作者: [Goto, Masanori, Shinmura, Kazuya, Nakabeppu, Yusaku, Tao, Hong, Yamada, Hidetaka, Tsuneyoshi, Toshihiro, Sugimura, Haruhiko]
通讯作者: Sugimura, Haruhiko
酸化的DNA損傷修復に関わる遺伝子多型とヒト発がん
基因多态性参与氧化DNA损伤修复和人类致癌作用
DOI: --
发表时间: 2011
期刊:
影响因子: --
作者: [要匡, その他, 椙村春彦]
通讯作者: 椙村春彦
14
    Pathological Significance of modified nucleic acid base in human tissue.
    • 批准号:
      24659161
    • 项目类别:
      Grant-in-Aid for Challenging Exploratory Research
    • 资助金额:
      $2.5万
    • 财政年份:
      2012
    • 负责人:
      SUGIMURA Haruhiko
    • 依托单位:
    Molecular pathological study of individual predisposition to gastric cancer
    • 批准号:
      15390125
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $9.66万
    • 财政年份:
      2003
    • 负责人:
      SUGIMURA Haruhiko
    • 依托单位:
    Lung cancer susceptibility gene and molecular pathology of lung cancer.
    • 批准号:
      08670243
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $1.41万
    • 财政年份:
      1996
    • 负责人:
      SUGIMURA Haruhiko
    • 依托单位:
    海外基金