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Development and the clinical application of the caqrdiovascular operation support program applied hydrodynamics simulation

应用流体力学模拟的心血管手术支持程序的开发及临床应用

基本信息

批准号：
22659252
负责人：
UENO Takayoshi
金额：
$ 2.11万
依托单位：
Osaka University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Challenging Exploratory Research
财政年份：
2010
资助国家：
日本
起止时间：
2010 至 2011
项目状态：
已结题

项目摘要

With the recent advancement of imaging technology in the medical field, more sophisticated information are now at our hand. Application of novel imaging modality into establishing computational model to simulate the outcome of cardiac surgery is envisioned. Among various factors, blood flow velocity is one of the key components in establishing the hydrodynamic model simulating the circulatory physiology of specific cardiac defects. The novel phase contrast cardiac magnetic resonance imaging(PC-CMR) technique enables the measurement of blood flow velocity at any point of interests in human. Hence, we investigated the possibility of PC-CMR in evaluating the hydrodynamics in patients with Fontan physiology. The study revealed that, compared with normal circulation, Fontan physiology is liable to have,# 1 : less cardiac output with higher systemic flow resistance,# 2 : more systemic to pulmonary collateral flow volume in association with higher systemic resistance,# 3 : more atrio-ventricular valve regurgitation,# 4 : more collateral flow volume, which correlated with degree of cyanosis as well as with age at Fontan operation. Thus, PC-CMR is highly informative in simulating and analyzing the specific circulation physiology, as well as estimating the outcome of cardiac surgery.

随着最近医学领域成像技术的进步，我们现在可以获得更复杂的信息。应用新型的成像模式建立计算模型，模拟心脏手术的结果进行了展望。在众多因素中，血流速度是建立模拟特定心脏缺损循环生理的流体力学模型的关键因素之一。新型相位对比心脏磁共振成像（PC-CMR）技术能够测量人体任何感兴趣点的血流速度。因此，我们研究了PC-CMR评估Fontan生理患者流体动力学的可能性。该研究显示，与正常循环相比，Fontan生理学易于具有# 1：心输出量较少，体循环阻力较高，# 2：体循环至肺循环侧支流量较多，体循环阻力较高，# 3：房室瓣返流较多，# 4：侧支血流量增加，与发绀程度及Fontan手术时年龄有关。因此，PC-CMR在模拟和分析特定的循环生理以及估计心脏手术的结果方面具有高度的信息性。