Functional relation of stress response in blood cells and brain after hypoxia

点击翻译按钮获取中文摘要

Biological stress determines recovery from emergency conditions, such as accidents and surgery and affects intracellular signal transduction. Diacylglycerol kinase (DGK) is an enzyme that metabolizes the second messenger DG in phosphoinositide turnover. Recent studies have indicated an involvement of diacylglycerol kinase (DGK) in various diseases such as cancer, diabetes, inflammation and stroke. In the present study we performed an experiment at the organismal level using hypoxic chamber stress (oxygen concentration 5%). After 3 days of transient hypoxic stress, we found that DGKζ was translocated from the nucleus to the cytoplasm. These results provide an evidence that nucleo-cytoplasmic translocation of DGKζ may be an index of early phase of apoptosis.