Identification of tumor-cell producing novel endogenous analgesic substance

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Injury to peripheral or spinal nerves following either trauma or disease has several consequences including the development of neuropathic pain. This syndrome is often refractory against conventional analgesics; and thus, novel medicaments are desired for its treatment. This study provided evidence in support of the tumor cells produce novel endogenous opioids. Our findings suggest that a CNS μ-opioid-receptor dependent mechanism tonically modulates early and late-stage bone cancer pain in cancer-bearing mice. Regulation of production or secretion of endogenous opioids and mechanisms of its analgesic may be targets for future innovations for chronic intractable pain including cancer or neuropathic pain management.