Identification of tumor-cell producing novel endogenous analgesic substance

肿瘤细胞产生新型内源性镇痛物质的鉴定

• 批准号: 22659337
• 负责人: MORITA Katsuya
• 金额: $ 2.11万
• 依托单位: Hiroshima University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22659337/
• 关键词: 歯科薬理学; 疼痛; がん性疼痛; 神経障害性疼痛; 新規内因性鎮痛関連物質; がん細胞培養上清

Injury to peripheral or spinal nerves following either trauma or disease has several consequences including the development of neuropathic pain. This syndrome is often refractory against conventional analgesics; and thus, novel medicaments are desired for its treatment. This study provided evidence in support of the tumor cells produce novel endogenous opioids. Our findings suggest that a CNS μ-opioid-receptor dependent mechanism tonically modulates early and late-stage bone cancer pain in cancer-bearing mice. Regulation of production or secretion of endogenous opioids and mechanisms of its analgesic may be targets for future innovations for chronic intractable pain including cancer or neuropathic pain management.

创伤或疾病后对周围神经或脊神经的损伤具有几种后果，包括神经性疼痛的发展。这种综合征通常对常规镇痛药是难治的;因此，需要新的药物用于其治疗。本研究为肿瘤细胞产生新型内源性阿片类物质提供了证据。我们的研究结果表明，中枢神经系统μ-阿片受体依赖性机制紧张性调节早期和晚期骨癌疼痛的荷癌小鼠。调节内源性阿片类物质的产生或分泌及其镇痛机制可能是未来慢性顽固性疼痛（包括癌症或神经性疼痛管理）创新的目标。