Role of Wnt-Ror2 signals in ruffled border formation in osteoclasts
Role of Wnt-Ror2 signals in ruffled border formation in osteoclasts
批准号:
22659339
负责人:
TAKAHASHI Naoyuki
金额:
$2.04万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Challenging Exploratory Research
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2011
中文摘要
点击翻译按钮获取中文摘要
英文摘要
The role of Wnt5a-Ror2 signals in osteoclast function was studied. (1) Bone-resorbing activities of osteoclasts derived from Wnt5a-deficient mice and from Ror2 deficient mice were lower than that of wild-type(WT) osteoclasts. (2) Wnt5a activated Rho, a small G protein, in WT osteoclasts but not in Ror2-deficient osteoclasts. (3) When active Rho was transfected into Ror2-deficient osteoclasts, the bone-resorbing activity was recovered. Thus, Wnt5a-Ror2 signals play important roles in osteoclast function through a Rho-dependent mechanism.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
登录
查看更多内容
分子メカニズムを知る意味とは(招待講演)
了解分子机制的意义是什么?(特邀报告)
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[HG Wang, N Kawashima, T Iwata, J Xu, S Takahashi, T Sugiyama, H Suda, 高橋直之]
通讯作者:
高橋直之
骨吸収を調節する骨芽細胞の新しい役割(招待講演)
成骨细胞在调节骨吸收中的新作用(特邀报告)
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[辺見浩一, 池田英治, 須田英明, 高橋直之]
通讯作者:
高橋直之
DOI:
10.1002/jbmr.89
发表时间:
2010-09-01
期刊:
JOURNAL OF BONE AND MINERAL RESEARCH
影响因子:
6.2
作者:
[Aoki, Shigeki, Honma, Masashi, Suzuki, Hiroshi]
通讯作者:
Suzuki, Hiroshi
骨吸収を調節する骨芽細胞の新しい役割
成骨细胞在调节骨吸收中的新作用
DOI:
--
发表时间:
2007
期刊:
影响因子:
--
作者:
[Yamashita T, et. al., Takahashi N, Takahashi N, Naoyuki Takahashi, 高橋 直之]
通讯作者:
高橋 直之
DOI:
10.1083/jcb.200806139
发表时间:
2009-02-23
期刊:
The Journal of cell biology
影响因子:
--
作者:
[Mizoguchi T, Muto A, Udagawa N, Arai A, Yamashita T, Hosoya A, Ninomiya T, Nakamura H, Yamamoto Y, Kinugawa S, Nakamura M, Nakamichi Y, Kobayashi Y, Nagasawa S, Oda K, Tanaka H, Tagaya M, Penninger JM, Ito M, Takahashi N]
通讯作者:
Takahashi N
共 24 条
Do carbon nanotubes control bone remodeling?
-
批准号:24659833
-
项目类别:Grant-in-Aid for Challenging Exploratory Research
-
资助金额:$2.41万
-
财政年份:2012
-
负责人:TAKAHASHI Naoyuki
-
依托单位:
Analysis of osteoclast niche regulated by Wnt signals.
-
批准号:22390351
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$12.31万
-
财政年份:2010
-
负责人:TAKAHASHI Naoyuki
-
依托单位:
The relationship between cell proliferation and RANKL-induced osteoclastogenesis
-
批准号:18390495
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$11.15万
-
财政年份:2006
-
负责人:TAKAHASHI Naoyuki
-
依托单位:
Study on the molecular mechanism of alveolus bone resorption induced periodontal diseases
-
批准号:16390535
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$9.15万
-
财政年份:2004
-
负责人:TAKAHASHI Naoyuki
-
依托单位:
Signal transduction and cell-to-cell communication in the bone resorption induced by inflammation
-
批准号:14370599
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$8.83万
-
财政年份:2002
-
负责人:TAKAHASHI Naoyuki
-
依托单位:
Study on mechanism of the coupling between bone resorption and bone formation
-
批准号:13557155
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$8.96万
-
财政年份:2001
-
负责人:TAKAHASHI Naoyuki
-
依托单位:
The invention of interstitial-type metal nitride thin films with opto-agilent function and their device fabrication
-
批准号:13305047
-
项目类别:Grant-in-Aid for Scientific Research (A)
-
资助金额:$31.62万
-
财政年份:2001
-
负责人:TAKAHASHI Naoyuki
-
依托单位:
Analysis of signal transduction of inflammatory cytokines in bone destruction
-
批准号:12470393
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$10.56万
-
财政年份:2000
-
负责人:TAKAHASHI Naoyuki
-
依托单位:
Study on signal transduction in osteoclastogenesis for the development of anti-osteoporosis drugs.
-
批准号:11557139
-
项目类别:Grant-in-Aid for Scientific Research (B).
-
资助金额:$8.64万
-
财政年份:1999
-
负责人:TAKAHASHI Naoyuki
-
依托单位:
Study on osteoclast activiting factor expressed by osteoblasts/stromal cells
-
批准号:10470394
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$8.26万
-
财政年份:1998
-
负责人:TAKAHASHI Naoyuki
-
依托单位:
Analysis of gp130-induced signals which regulate osteclast formation and function
-
批准号:07457441
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$4.74万
-
财政年份:1995
-
负责人:TAKAHASHI Naoyuki
-
依托单位:
Establishment of assay systems for examining bone metabolism : Studies on differentiation and function of osteoblasts and osteoclasts
-
批准号:07557118
-
项目类别:Grant-in-Aid for Scientific Research (A)
-
资助金额:$7.74万
-
财政年份:1995
-
负责人:TAKAHASHI Naoyuki
-
依托单位:
Analysis of signaling pathways involved in polarization of osteoclasts.
-
批准号:05454507
-
项目类别:Grant-in-Aid for General Scientific Research (B)
-
资助金额:$4.22万
-
财政年份:1993
-
负责人:TAKAHASHI Naoyuki
-
依托单位:
Development of Co-operation Diagnostic System for Facial Asymmetry Patient derived from Morphology and Function.
-
批准号:05671699
-
项目类别:Grant-in-Aid for General Scientific Research (C)
-
资助金额:$1.34万
-
财政年份:1993
-
负责人:TAKAHASHI Naoyuki
-
依托单位:
Study on Interaction between Osteoclast Progenitors and Osteoblastic Cells in Osteoclast Development.
-
批准号:03454437
-
项目类别:Grant-in-Aid for General Scientific Research (B)
-
资助金额:$3.9万
-
财政年份:1991
-
负责人:TAKAHASHI Naoyuki
-
依托单位:
Rolo of Osteoblastic Cells in Osteoclast Development.
-
批准号:01480437
-
项目类别:Grant-in-Aid for General Scientific Research (B)
-
资助金额:$3.71万
-
财政年份:1989
-
负责人:TAKAHASHI Naoyuki
-
依托单位:
海外基金