Basic research for oral cancer diagnosis estimated by HuR export

本研究探讨了HuR在口腔癌细胞中的定位、胞浆中HuR的表达与口腔癌的恶性程度、胞浆中HuR与癌前病变的关系。含有HuR和AU的mRNA被输出到口腔癌细胞的细胞质中。恶性度高的癌症和诊断不佳的癌前病变中细胞质HuR表达增加。提示HuR定位可作为癌前病变的诊断工具。

I this study, we examined the localization of HuR in oral cancer cells, the cytoplasmic expression of HuR and malignancy, the relation between cytoplasmic HuR and precancerous change. HuR and AU-rich containing mRNA were exported to the cytoplasm of oral cancer cells. Cytoplasmic HuR expression increased in the cancer which had high malignancy and in the precancerous change which showed poor diagnosis. These findings suggest that the localization of HuR is available for diagnostic tool of precancerous change.