The oral immunological effect on bisphosphonate-treated mice model by periodontal disease associated-pathogen

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By using periodontal disease-associated pathogen-infected mice long-termed administered with bisphosphonate substrates, we showed long-term colonization of periodontal disease-associated bacterium and the accumulation of inflammatory cells in teeth extraction wound of the oral cavity. In addition, we displayed induction of osteoclasts differentiation-associated cytokines from CD4 T cells and MФof teeth extraction wound. Taken together, it was suggested that the existence of periodontal disease-associated bacterium had effect on the progress and outbreak of bisphosphonate-related Osteonecrosis of the Jaw.