Analysis of the mechanisms of an RNase, Zc3h12a-mediated immune regulation.
Analysis of the mechanisms of an RNase, Zc3h12a-mediated immune regulation.
批准号:
22689016
负责人:
TAKEUCHI Osamu
金额:
$15.97万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (A)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2012
中文摘要
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英文摘要
In this study, we examined the role of an RNase Regnase-1 (also known as Zc3h12a) in the prevention of the development of autoimmune diseases, and found that Regnase-1 expressed in T cells as well as macrophages is critical for this task. Furthermore, Regnase-1 protein expression is dramatically regulated in the course of inflammation in these cells.
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Control of inflammation by Toll-like receptor-inducible genes
Toll 样受体诱导基因控制炎症
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[A.Nakayama, H.Matsuo. T.Takada, K.Ichida, T.Nakamura, Y.Ikebuchi, K.Ito, T.Hosoya, Y.Kanai, H.Suzuki, N.Shinomiya, 國澤純, Hase K., Saito-Kokusho T, Osamu Takeuchi]
通讯作者:
Osamu Takeuchi
RNA分解酵素Regnase-1による自然免疫制御
RNA 降解酶 Regnase-1 的先天免疫调节
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[Takamasa Ishii, et al, 竹内 理]
通讯作者:
竹内 理
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Masaki Miyazawa, et al., Osamu Takeuchi]
通讯作者:
Osamu Takeuchi
Zc3h12a is an RNase promoting Interleukin 6 mRNA decay and regulates immune responses.
Zc3h12a 是一种 RNase,可促进白细胞介素 6 mRNA 衰变并调节免疫反应。
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Jun Kunisawa, Takahiro Nagatake, Takashi Obata, Naoko Shibata, and Hiroshi Kiyono, Osamu Takeuchi]
通讯作者:
Osamu Takeuchi
Zc3h12a, an RNase promoting Interleukin 6 mRNA decay, undergoes posttranscriptional modification to pathogenic stimuli
Zc3h12a 是一种促进白细胞介素 6 mRNA 衰变的 RNase,对致病刺激进行转录后修饰
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Takamasa Ishii, et al., Osamu Takeuchi]
通讯作者:
Osamu Takeuchi
共 22 条
Depression of dentin and dental pulp complex tissue destruction in MMPs analysis and development of a new adhesion system
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批准号:16K20475
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项目类别:Grant-in-Aid for Young Scientists (B)
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资助金额:$2.41万
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财政年份:2016
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负责人:TAKEUCHI Osamu
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依托单位:
Elucidation of dental pulp cell differentiation by laser
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批准号:23792197
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项目类别:Grant-in-Aid for Young Scientists (B)
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资助金额:$2.41万
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财政年份:2011
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负责人:TAKEUCHI Osamu
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依托单位:
Development and application of scanning tunneling miscroscope that has femtosecond time resolution
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批准号:22686005
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项目类别:Grant-in-Aid for Young Scientists (A)
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资助金额:$16.72万
-
财政年份:2010
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负责人:TAKEUCHI Osamu
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依托单位:
Establishing the Cerebral Basis for Language Learner Strategies : From the Perspectives of Working Memory Activation and Learner Training.
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批准号:20520540
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项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$3.0万
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财政年份:2008
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负责人:TAKEUCHI Osamu
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依托单位:
EFL reading strategies and their instruction on e-learning : Toward the construction of an instructional model
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批准号:18520466
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.69万
-
财政年份:2006
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负责人:TAKEUCHI Osamu
-
依托单位:
海外基金