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Analysis of the mechanisms of an RNase, Zc3h12a-mediated immune regulation.

Analysis of the mechanisms of an RNase, Zc3h12a-mediated immune regulation.
RNase、Zc3h12a 介导的免疫调节机制分析。
批准号:
22689016
负责人:
TAKEUCHI Osamu
金额:
$15.97万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (A)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2012

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中文摘要
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英文摘要
In this study, we examined the role of an RNase Regnase-1 (also known as Zc3h12a) in the prevention of the development of autoimmune diseases, and found that Regnase-1 expressed in T cells as well as macrophages is critical for this task. Furthermore, Regnase-1 protein expression is dramatically regulated in the course of inflammation in these cells.
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会议论文
Control of inflammation by Toll-like receptor-inducible genes
Toll 样受体诱导基因控制炎症
DOI: --
发表时间: 2011
期刊:
影响因子: --
作者: [A.Nakayama, H.Matsuo. T.Takada, K.Ichida, T.Nakamura, Y.Ikebuchi, K.Ito, T.Hosoya, Y.Kanai, H.Suzuki, N.Shinomiya, 國澤純, Hase K., Saito-Kokusho T, Osamu Takeuchi]
通讯作者: Osamu Takeuchi
RNA分解酵素Regnase-1による自然免疫制御
RNA 降解酶 Regnase-1 的先天免疫调节
DOI: --
发表时间: 2012
期刊:
影响因子: --
作者: [Takamasa Ishii, et al, 竹内 理]
通讯作者: 竹内 理
Mechanisms of innate immune recognition to virus infection
先天免疫识别病毒感染的机制
DOI: --
发表时间: 2010
期刊:
影响因子: --
作者: [Masaki Miyazawa, et al., Osamu Takeuchi]
通讯作者: Osamu Takeuchi
Zc3h12a is an RNase promoting Interleukin 6 mRNA decay and regulates immune responses.
Zc3h12a 是一种 RNase,可促进白细胞介素 6 mRNA 衰变并调节免疫反应。
DOI: --
发表时间: 2010
期刊:
影响因子: --
作者: [Jun Kunisawa, Takahiro Nagatake, Takashi Obata, Naoko Shibata, and Hiroshi Kiyono, Osamu Takeuchi]
通讯作者: Osamu Takeuchi
22
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    • 资助金额:
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