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Systematic analyses of modes of migration, differentiation andfunction of bone-resorbing osteoclasts visualized by intravitalimaging

Systematic analyses of modes of migration, differentiation andfunction of bone-resorbing osteoclasts visualized by intravitalimaging
活体成像可视化破骨细胞迁移、分化和功能模式的系统分析
批准号:
22689030
负责人:
ISHII Masaru
金额:
$12.56万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (A)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2012

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中文摘要
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英文摘要
The main subject of this study is to reveal the cellular dynamics in various kinds of tissues and organs in vivo, by using advanced imaging techniques, especially focusing on the dynamic phenomenon within bone marrow cavity. By improving the optical technology, we developed an intravital bone imaging system that enabled elucidation of control mechanisms for dynamic behaviors of bone-resorbing osteoclasts in vivo. We also developed novel anti-bone resorptive treatments based on our findings.
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DOI: 10.1073/pnas.1114931109
发表时间: 2012-03-27
期刊: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
影响因子: 11.1
作者: [Kayama, Hisako, Ueda, Yoshiyasu, Takeda, Kiyoshi]
通讯作者: Takeda, Kiyoshi
DOI: 10.4049/jimmunol.1201345
发表时间: 2013-01-15
期刊: JOURNAL OF IMMUNOLOGY
影响因子: 4.4
作者: [Kotani, Manato, Kikuta, Junichi, Ishii, Masaru]
通讯作者: Ishii, Masaru
DOI: 10.1038/nn.3358
发表时间: 2013-05-01
期刊: NATURE NEUROSCIENCE
影响因子: 25
作者: [Ueno, Masaki, Fujita, Yuki, Yamashita, Toshihide]
通讯作者: Yamashita, Toshihide
Dynamic analysis of histamine-mediated attenuation of acetylcholine-induced sweating via GSK3beta activation
通过 GSK3beta 激活组胺介导的乙酰胆碱诱导出汗减弱的动态分析
DOI: --
发表时间: 2013
期刊: J. Invest. Dermatol
影响因子: --
作者: [Matsui S, Murota H, Takahashi A, Yang A, Lee J-B, Omiya K, Ohmi M, Kikuta J, Ishii M, Katayama I]
通讯作者: Katayama I
21
    Development of novel methods for evaluating RA pathogenesis and activity
    • 批准号:
      25253070
    • 项目类别:
      Grant-in-Aid for Scientific Research (A)
    • 资助金额:
      $28.79万
    • 财政年份:
      2013
    • 负责人:
      ISHII Masaru
    • 依托单位:
    Dynamic in vivo imaging of osteoclast functions for development of novel therapeutics against bone-resorptive disorders
    Return-Stroke Modeling Based on Observation of Close Electromagnetic Fields
    • 批准号:
      16560240
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.37万
    • 财政年份:
      2004
    • 负责人:
      ISHII Masaru
    • 依托单位:
    Effects of urbanization on health and fitness of East Asian children in view points of physiological anthropology
    • 批准号:
      15207022
    • 项目类别:
      Grant-in-Aid for Scientific Research (A)
    • 资助金额:
      $25.79万
    • 财政年份:
      2003
    • 负责人:
      ISHII Masaru
    • 依托单位:
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