Virotherapy for bone and soft tissue sarcoma by telomerase-specific oncolytic adenovirus
Virotherapy for bone and soft tissue sarcoma by telomerase-specific oncolytic adenovirus
批准号:
22689040
负责人:
KAWASHIMA Hiroyuki
金额:
$5.24万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (A)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2012
中文摘要
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英文摘要
Bone and soft tissue sarcoma cells treated by telomerase-specific oncolytic adenovirus showed a dose- and time-dependent viral replication and cytolysis, which were positively associated with the expression levels of coxackie-adenoviral receptor and hTERT. Oncolytic adenoviral infection also induced both apototic and autophagic cell death in these cells, and also showed inhibition of tumor growth in osteosarcoma xenograft mouse model.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Telomelysin exhibits potent anti-tumor activity via apoptotic and non-apoptotic cell death in softtissue sarcoma cells
Telomelysin 通过软组织肉瘤细胞中的凋亡和非凋亡细胞死亡表现出有效的抗肿瘤活性
DOI:
--
发表时间:
2013
期刊:
Cancer Sci
影响因子:
5.7
作者:
[Guidong Li, Hiroyuki Kawashima, et al]
通讯作者:
et al
ヒト軟部肉腫におけるテロメラーゼ特異的制限増殖型ウイルス、テロメライシン(OBP-301)の抗腫瘍効果
端粒酶特异性限制性复制病毒端粒霉素(OBP-301)对人软组织肉瘤的抗肿瘤作用
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[李貴東, ほか]
通讯作者:
ほか
ヒト骨肉腫細胞株およびマウス移植モデルにおけるテロメラーゼ特異的制限増殖型ウイルスの抗腫瘍効果
端粒酶特异性限制性病毒对人骨肉瘤细胞系和小鼠移植模型的抗肿瘤作用
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[李貴東, 川島寛之ほか]
通讯作者:
川島寛之ほか
Development of new treatment for intractable inflammatory bowel disease using exosome derived from DFAT
-
批准号:17K17007
-
项目类别:Grant-in-Aid for Young Scientists (B)
-
资助金额:$2.66万
-
财政年份:2017
-
负责人:KAWASHIMA Hiroyuki
-
依托单位:
Indian future interpreted from the gap between agriculture andmanufacturing
-
批准号:23658181
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.5万
-
财政年份:2011
-
负责人:KAWASHIMA Hiroyuki
-
依托单位:
Systemic Gene Therapy for Osteosarcoma by Tumor Suppressor Gene Fus1
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批准号:19791021
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项目类别:Grant-in-Aid for Young Scientists (B)
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资助金额:$2.01万
-
财政年份:2007
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负责人:KAWASHIMA Hiroyuki
-
依托单位:
Cell-specific response to mechanical stress and regulatory mechanism of differentiation : ligament/tendon cells versus osteoblasts
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批准号:16390531
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$9.09万
-
财政年份:2004
-
负责人:KAWASHIMA Hiroyuki
-
依托单位:
Molecular mechanism of osteogenesis-induced osteogenesis
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批准号:14370591
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项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$8.9万
-
财政年份:2002
-
负责人:KAWASHIMA Hiroyuki
-
依托单位:
On the analysis and regulatory mechanism of genes responsible for mechanical stress-induced osteoblast differentiation and osteogenesis
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批准号:12470389
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$9.34万
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财政年份:2000
-
负责人:KAWASHIMA Hiroyuki
-
依托单位:
Mechanism of mechanical stress-induced osteoblast differentiation and osteogenesis
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批准号:10470388
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$8.19万
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财政年份:1998
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负责人:KAWASHIMA Hiroyuki
-
依托单位: