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Investigating brain function that is affected by alteration of arousal level

研究受唤醒水平改变影响的大脑功能

基本信息

批准号：
22700287
负责人：
KOIKE Takahiko
金额：
$ 2.5万
依托单位：
National Institute for Physiological Sciences (2011-2012)National Institute of Information and Communications Technology (2010)
依托单位国家：
日本
项目类别：
Grant-in-Aid for Young Scientists (B)
财政年份：
2010
资助国家：
日本
起止时间：
2010 至 2012
项目状态：
已结题

项目摘要

Empirically, we know that decreased arousal level causes decreased performance, and that the decrease of performance might be due to alteration of brain activity. In this study, we have attempted to identify the relationship across decreasing arousal level, decreasing human performance, and alteration of brain activity by combining the electro- encephalogram (EEG) recording, functional magnetic resonance imaging (fMRI) and psychological tasks. Firstly, we tested our idea with alteration of arousal level between sleep stages. Our analysis revealed that there is significant difference of functional connectivity on the prefrontal component of default mode network (DMN), which have an essential role in keeping arousal level and consciousness level. Secondly, by combining graph-theory and EEG-fMRI simultaneous recording, we investigated changes in brain network structure associated with arousal level decrease during wakefulness. The analysis identified that the DMN and visual area is prominently influenced by decrease of arousal level. Thirdly, our study found that the optokinetic nystagmus (OKN), which is a reflective eye movement, is also affected by slight decrease of arousal level during wakefulness with eyes-opened. Our consequent research shows that the brain network structure is altered by decrease of arousal even participants feel they are perfectly awake.

从经验上讲，我们知道唤醒水平的降低会导致表现的下降，而表现的下降可能是由于大脑活动的改变。在本研究中，我们试图通过结合脑电图（EEG）记录、功能磁共振成像（fMRI）和心理任务来确定唤醒水平降低、人类行为能力降低和大脑活动改变之间的关系。首先，我们通过改变睡眠阶段之间的唤醒水平来测试我们的想法。分析结果表明，在保持唤醒水平和意识水平方面起重要作用的默认模式网络（DMN）的前额叶成分的功能连接存在显著差异。其次，结合图论和脑电功能磁共振成像同步记录，我们研究了觉醒水平下降时大脑网络结构的变化。分析表明，DMN和视觉面积显着影响唤醒水平的降低。第三，我们的研究发现，视动性眼震（OKN），这是一种反射性的眼球运动，也受到唤醒水平的轻微下降，在清醒状态下睁开眼睛。我们随后的研究表明，即使参与者感觉他们完全清醒，大脑网络结构也会因唤醒程度的降低而改变。