课题基金 / 基金详情

Regulation of synaptic structural plasticity : Involvement of Rho family GTPases by photoactivatable proteins

Regulation of synaptic structural plasticity : Involvement of Rho family GTPases by photoactivatable proteins
突触结构可塑性的调节：光激活蛋白参与 Rho 家族 GTP 酶
批准号：
22700359
负责人：
SANEYOSHI Takeo
金额：
$2.66万
依托单位：
The Institute of Physical and Chemical Research
依托单位国家：
日本
项目类别：
Grant-in-Aid for Young Scientists (B)
财政年份：
2010
资助国家：
日本
项目状态：
已结题
起止时间：
2010 至 2011
来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22700359/
关键词：
光活性化タンパク質スパインシナプス構造可塑性アクチン細胞骨格2光子顕微鏡カルシウムRho GTPaseシナプス可塑性海馬アクチン

项目摘要

项目成果

SANEYOSHI Takeo的其他基金

相似基金

相关文献

中文摘要
翻译
点击翻译按钮获取中文摘要
英文摘要
Rac has been implicated in actin remodeling in cells. In this study we tested roles of Rac signaling in structural plasticity of synapse in hippocampal neuron. We found that inhibitors of Rac and its regulators inhibited synapse structural plasticity, and activation of Rac signaling by photoactivatable Rac in a dendritic spine caused spine expansion. These results indicate that Rac is necessary and sufficient for synapse structural plasticity. In addition, we succeeded to generate photoactivatable CaMKII.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
The Ca2+and Rho GTPases pathways underlying activity-dependent actin remodeling at dendritic spines
Ca2 和 Rho GTPases 通路是树突棘活性依赖性肌动蛋白重塑的基础
DOI： --
发表时间： 2012
期刊： Cytoskeleton
影响因子： 2.9
作者： [Yoko Yazaki-Sugiyama, Jason Kushner, Neal A Hessler, Takao K Hensch, 杉山陽子(矢崎陽子), 杉山(矢崎)陽子, Takeo Saneyoshi and Yasunori Hayashi]
通讯作者： Takeo Saneyoshi and Yasunori Hayashi
Positive feedback loop of Rac activity on synapse structural plasticity
Identification of cellular substrate for CaMKII using unnatural amino acid incorporation
  • 批准号：
    24650204
  • 项目类别：
    Grant-in-Aid for Challenging Exploratory Research
  • 资助金额：
    $2.5万
  • 财政年份：
    2012
  • 负责人：
    SANEYOSHI Takeo
  • 依托单位：
    Institute of Physical and Chemical Research
海外基金