Analyses of N-terminal processing of secretory lectin PAP-III in neuronal regeneration

我发现N-末端加工的PAP-III（ΔN-PAP-III）形成纤维状结构并紧密附着在神经元表面。当在培养皿上制备致密的ΔN-PAP-III纤维网络时，神经突优先粘附于ΔN-PAP-III纤维，并且神经突延伸增强。这些结果表明PAP-III可能在损伤部位周围形成不溶性纤维状结构，并为再生轴突提供伸长的平台。

I revealed that N-terminal processed PAP-III(ΔN-PAP-III) formed fibrillar structures and attached tightly to neuronal surfaces. When a dense networks ofΔN-PAP-III fibers were prepared on the culture dishes, neurites preferentially adhere to theΔN-PAP-III fibers and neurite extension was enhanced. These results suggest a possibility that PAP-III may form insoluble fibrillar structures around injury site and would provide regenerating axons with a platform for elongation.