Sulfation patterns and molecular mechanisms of Chondroitin sulfate polysaccharide in regulating the neuronal regeneration

硫酸软骨素是中枢神经系统细胞表面和细胞外基质的重要组成部分。根据其主要双糖单元的硫酸盐化模式，CS至少分为四个亚类，称为CS-A、CS-C、CS-D和CS-E。CS-E多糖对培养神经元细胞的黏附和形态无明显影响，而CS-A、CS-C和CS-D多糖对细胞黏附和形态无明显影响。CS-E多糖的作用是通过血管内皮生长因子受体/eNOS和血管内皮生长因子受体/Raf-1/Rb信号途径实现的。

Chondroitin sulfate(CS) is an important component of the cell surface and extracellular matrix in the central nervous system. CS is divided into at least four subclasses, known as CS-A, CS-C, CS-D and CS-E, on the basis of the sulfation patterns of their major disaccharide units. The CS-E polysaccharide, but not CS-A, CS-C or CS-D polysaccharide, was changed cell adhesion and mourphology of cultured neuronal cells. The action of CS-E polysaccharide is mediated through VEGF receptor/eNOS and VEGF receptor/Raf-1/Rb signalings.