Regulation of neuronal regeneration by chondroitin sulfate

硫酸软骨素（CS）是中枢神经系统细胞表面和细胞外基质的重要组成部分。根据其主要二糖单元的硫酸化模式，CS至少分为四个亚类，称为CS-A、CS-C、CS-D和CS-E。CS-E多糖对神经干细胞的粘附性有明显的影响，而CS-A、CS-C和CS-D多糖对神经干细胞的粘附性无明显影响。CS-E多糖处理的神经干细胞中，包括H2-Q6（组织相容性2，I类抗原）和CCL 12（趋化因子（C-C基序）配体12）在内的几个基因的mRNA水平增强。

Chondroitin sulfate (CS) is an important component of the cell surface and extracellular matrix in the central nervous system. CS is divided into at least four subclasses, known as CS-A, CS-C, CS-D and CS-E, on the basis of the sulfation patterns of their major disaccharide units. The CS-E polysaccharide, but not CS-A, CS-C or CS-D polysaccharide, was changed cell adhesion of neural stem cells. Several genes including H2-Q6 (histocompatibilty 2, class I antigen) and CCL12 (chemokine (C-C motif) ligand 12) were enhanced mRNA levels in CS-E polysaccharide-treated neural stem cells.