Screening and functional screening of the genes which regulate the proliferation of Muller glia in damaged retina.

在这项研究中，我们发现B6小鼠视网膜损伤后Muller胶质细胞的增殖程度明显低于其他品系的小鼠。此外，GSK3抑制剂的加入不影响B6小鼠受损视网膜中Muller胶质细胞的增殖，而GSK3抑制剂显著增加其他品系小鼠视网膜中增殖的Muller神经胶质细胞的数量。通过比较B6和其他品系小鼠视网膜损伤后的全基因组基因表达，我们发现染色体重塑因子和天然免疫系统成分的表达模式与Muller胶质细胞的增殖有关。

In this research, we showed that the degree of proliferation of Muller glia after retinal damage was significantly less in B6 mice compared to other mouse strains. Furthermore, addition of GSK3 inhibitor did not affect the proliferation of Muller glia in the damaged retina from B6 mice, whereas GSK3 inhibitor significantly increased the number of proliferative Muller glia in other mouse strains. By comparing the genome-wide gene expression in retinas after damage between B6 and other mouse strain, we found that the expression patterns of chromosome remodeling factors and components of innate immune system were different associating with the proliferation of Muller glia.