Control of neural circuit formation using light-regulated adenylyl cyclase in vivo.

为了了解cAMP是如何在小鼠嗅觉感觉神经元（OSNs）中发挥各种功能的，我们培育了在小鼠嗅觉受体启动子控制下表达光激活腺苷酸环化酶PAC的转基因小鼠。整个OSN包括树突和轴突都检测到PAC，允许PAC局部激活。我们目前正在通过光调节PAC活性来分析cAMP在神经回路形成中的功能。

To understand how cAMP is used to exert various functions in mouse olfactory sensory neurons(OSNs), we generated transgenic mice in which PAC, photo-activated adenylate cyclase, is expressed under the control of the mouse olfactory receptor promoter. PAC was detected throughout OSN including dendrites and axons, allowing local activation of PAC. We are currently analyzing the function of cAMP in neural circuit formation by regulating PAC activity using light.