Development of infertility treatment model using infertile mice and iPS cells

对生殖细胞丧失患者的不育治疗根本不存在。在本研究中，我们尝试使用具有性染色体异常的XXY型小鼠作为Klinefelter综合征模型来开发生殖细胞丢失治疗模型。首先，为了再生生殖细胞，我们尝试建立诱导多能干细胞（iPS）。一些iPS细胞样系能够建立。然而，外源基因不能从iPS细胞样系中去除。结果，生殖细胞的再生没有达到。

Infertility treatment for patients with germ cell loss does not exist at all. In this study, we attempt to develop a germ cell loss treatment model using a XXY type mouse which has the sex chromosome abnormality as Klinefelter' s syndrome model. First, in order to regenerate the germ cells, we attempted the establishment of induced pluripotent stem cell(iPS). Some iPS cell-like lines were able to establish. However, the foreign gene could not be removed from iPS cell-like lines. As a result, the regeneration of germ cells did not reach.