Development of human antibody producing mice with human immune systems

点击翻译按钮获取中文摘要

The purpose in this research is producing humanized mice reconstituted with human immune system. We obtained 2 strains of human gene transgenic (Tg) mice (HLA-DR4 Tg, IL-3/GM-CSF Tg), and human HSCs were transferred into them to analyze human immune responses in vivo. HLA-DR4 Tg mice showed the production of an antigen specific human IgG antibody and promotion of T cell activity. Meanwhile, differentiation of human mast cells and basophils were increased in hIL-3/GM Tg mice, and they could induce passive allergic response in vivo. Therefore, these humanized Tg mice may contribute to medical research such as the pre-clinical study on the development of new drug.