Fabrication of artificial bone cements with anti-tumor effects and evaluation of their biological properties

在本研究中，我们用六磷酸肌醇（IP6）修饰HAp颗粒制备了“螯合型磷灰石胶结物（IP6-HAp胶结物）”，并对其抗肿瘤效果进行了评价。骨肉瘤在IP6- hap骨水泥（超过3000 ppm IP6）上培养，导致细胞生长受到抑制，尽管正常细胞在这些骨水泥上生长良好。这些结果使我们认为，从水泥中释放的局部高浓度IP6直接作为抗肿瘤剂作用于细胞，诱导细胞凋亡。因此，IP6-HAp水泥可能获得抗肿瘤作用，并作为局部给药系统的载体。

In the present study, we have fabricated “chelate-setting apatite cements (IP6-HAp cements)” using HAp particles surface-modified with inositol hexaphosphate (IP6) and evaluated their anti-tumor effect. Osteosarcoma cultured on IP6-HAp cements (over 3000 ppm IP6) resulted in inhibition of cell growth, although normal cells grew well on those cements. These results led us to consider that locally high concentration of IP6 which was released from cement acts on the cells directly as anti-tumor agent and induces the apoptosis. Consequently, IP6-HAp cement might gain the anti-tumor effect and act as a carrier for local drug delivery system.